Format

Send to:

Choose Destination

Mat1a methionine adenosyltransferase I, alpha [ Mus musculus (house mouse) ]

Gene ID: 11720, updated on 30-Apr-2019

Summary

Official Symbol
Mat1aprovided by MGI
Official Full Name
methionine adenosyltransferase I, alphaprovided by MGI
Primary source
MGI:MGI:88017
See related
Ensembl:ENSMUSG00000037798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ams; MAT; SAMS; MATA1; SAMS1; AdoMet; AI046368
Summary
This gene encodes a member of the AdoMet synthase family. Methionine adenosyltransferase is a product of this gene (the alpha form) and the beta form and catalyzes the formation of S-adenosylmethionine from methionine and ATP.[provided by RefSeq, Jan 2013]
Expression
Restricted expression toward liver adult (RPKM 598.5) See more
Orthologs

Genomic context

See Mat1a in Genome Data Viewer
Location:
14; 14 B
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (41105008..41124428)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (41918670..41937701)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene peroxiredoxin like 2A Neighboring gene DPY30 domain containing 2 Neighboring gene DPY30 domain containing 1 Neighboring gene surfactant associated protein A1 Neighboring gene pleckstrin homology domain containing, family F (with FYVE domain) member 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ADP binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
amino acid binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methionine adenosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methionine adenosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
methionine adenosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
S-adenosylmethionine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
methionine catabolic process ISO
Inferred from Sequence Orthology
more info
 
one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nuclear matrix ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
S-adenosylmethionine synthase isoform type-1; S-adenosylmethionine synthase
Names
adoMet synthetase 1
NP_598414.1
XP_006518513.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133653.3NP_598414.1  S-adenosylmethionine synthase isoform type-1

    See identical proteins and their annotated locations for NP_598414.1

    Status: REVIEWED

    Source sequence(s)
    AC124400, AC154597, AK153832, BB807316, BB871001
    Consensus CDS
    CCDS26959.1
    UniProtKB/Swiss-Prot
    Q91X83
    Related
    ENSMUSP00000153488.1, ENSMUST00000225720.1
    Conserved Domains (4) summary
    PTZ00104
    Location:17394
    PTZ00104; S-adenosylmethionine synthase; Provisional
    pfam00438
    Location:19115
    S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
    pfam02772
    Location:130251
    S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
    pfam02773
    Location:253389
    S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    41105008..41124428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518450.2XP_006518513.1  S-adenosylmethionine synthase isoform X1

    See identical proteins and their annotated locations for XP_006518513.1

    UniProtKB/Swiss-Prot
    Q91X83
    Conserved Domains (4) summary
    PTZ00104
    Location:17394
    PTZ00104; S-adenosylmethionine synthase; Provisional
    pfam00438
    Location:19115
    S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain
    pfam02772
    Location:130251
    S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain
    pfam02773
    Location:253389
    S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain
Support Center