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AGAP6 ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 [ Homo sapiens (human) ]

Gene ID: 414189, updated on 24-Nov-2020

Summary

Official Symbol
AGAP6provided by HGNC
Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 6provided by HGNC
Primary source
HGNC:HGNC:23466
See related
Ensembl:ENSG00000204149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGAP-6; CTGLF3
Expression
Ubiquitous expression in testis (RPKM 10.9), skin (RPKM 8.4) and 25 other tissues See more

Genomic context

See AGAP6 in Genome Data Viewer
Location:
10q11.23
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (49988318..50010499)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (51732867..51770259)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene TIMM23B-AGAP6 readthrough (NMD candidate) Neighboring gene translocase of inner mitochondrial membrane 23 homolog B Neighboring gene small nucleolar RNA, H/ACA box 74C-2 Neighboring gene RNA, 5S ribosomal pseudogene 317 Neighboring gene family with sequence similarity 21, member A pseudogene Neighboring gene solute carrier family 9 member 3 pseudogene 3 Neighboring gene WASH complex subunit 2A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TIMM23B-AGAP6

Readthrough gene: TIMM23B-AGAP6, Included gene: TIMM23B

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6
Names
centaurin-gamma-like family member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077665.2NP_001071133.2  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL442003, BC131545
    Consensus CDS
    CCDS44397.1
    UniProtKB/Swiss-Prot
    Q5VW22
    Related
    ENSP00000500374.1, ENST00000412531.5
    Conserved Domains (6) summary
    cd00204
    Location:594677
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:280447
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:283442
    PH; PH domain
    pfam01412
    Location:466580
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:591681
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:591621
    ANK; ANK repeat [structural motif]
  2. NM_001365867.2NP_001352796.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL442003
    Conserved Domains (4) summary
    cd00204
    Location:393476
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:79246
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:390420
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:265379
    ArfGap; Putative GTPase activating protein for Arf

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    49988318..50010499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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