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TIMM23B translocase of inner mitochondrial membrane 23 homolog B [ Homo sapiens (human) ]

Gene ID: 100652748, updated on 4-Jul-2021

Summary

Official Symbol
TIMM23Bprovided by HGNC
Official Full Name
translocase of inner mitochondrial membrane 23 homolog Bprovided by HGNC
Primary source
HGNC:HGNC:23581
See related
Ensembl:ENSG00000204152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 3.8), bone marrow (RPKM 3.7) and 25 other tissues See more
Orthologs
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Genomic context

See TIMM23B in Genome Data Viewer
Location:
10q11.23
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (49942053..49974850)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (51371399..51734610)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10647 Neighboring gene poly(ADP-ribose) glycohydrolase Neighboring gene ribosomal protein L35a pseudogene 24 Neighboring gene TIMM23B-AGAP6 readthrough (NMD candidate) Neighboring gene small nucleolar RNA, H/ACA box 74C-2 Neighboring gene RNA, 5S ribosomal pseudogene 317 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Readthrough TIMM23B-AGAP6

Readthrough gene: TIMM23B-AGAP6, Included gene: AGAP6

Homology

Clone Names

  • FLJ40725, FLJ56773, FLJ57933, FLJ60010, FLJ79448, MGC22767

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in integral component of mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim23B
Names
putative mitochondrial import inner membrane translocase subunit Tim23B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290117.2NP_001277046.1  mitochondrial import inner membrane translocase subunit Tim23B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK098044, AK293228, AL542628, BU620107, BU928648, DC419977
    Consensus CDS
    CCDS73131.1
    UniProtKB/TrEMBL
    B4DDK6
    Related
    ENSP00000502369.1, ENST00000651259.3
    Conserved Domains (1) summary
    cl02381
    Location:46171
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
  2. NM_001290118.2NP_001277047.1  mitochondrial import inner membrane translocase subunit Tim23B isoform 2

    See identical proteins and their annotated locations for NP_001277047.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons in the coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK098044, AK293228, BU620107, BU928648, DA019889, DC419977
    Consensus CDS
    CCDS76301.1
    UniProtKB/TrEMBL
    B4DDK6
    Related
    ENSP00000502146.1, ENST00000652716.1
    Conserved Domains (1) summary
    cl02381
    Location:46123
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
  3. NM_001365871.1NP_001352800.1  mitochondrial import inner membrane translocase subunit Tim23B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL442003, FO393433, FP565721
    Conserved Domains (1) summary
    cl02381
    Location:187
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

RNA

  1. NR_110767.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK098044, AK293228, AL542628, BU620107, BU928648, DC419977
    Related
    ENST00000478381.5
  2. NR_158651.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL442003, FO393433, FP565721
  3. NR_158652.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL442003, FO393433, FP565721

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    49942053..49974850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_135475.1: Suppressed sequence

    Description
    NR_135475.1: This RefSeq has been removed because it is thought to be partial.
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