Format

Send to:

Choose Destination

MAP6 microtubule associated protein 6 [ Homo sapiens (human) ]

Gene ID: 4135, updated on 2-Oct-2018

Summary

Official Symbol
MAP6provided by HGNC
Official Full Name
microtubule associated protein 6provided by HGNC
Primary source
HGNC:HGNC:6868
See related
Ensembl:ENSG00000171533 MIM:601783; Vega:OTTHUMG00000165343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STOP; MTAP6; MAP6-N; N-STOP
Summary
This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 4.6), testis (RPKM 2.8) and 13 other tissues See more
Orthologs

Genomic context

See MAP6 in Genome Data Viewer
Location:
11q13.5
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (75586914..75668724, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (75297959..75379479, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1748 Neighboring gene serpin family H member 1 Neighboring gene uncharacterized LOC105369391 Neighboring gene ribosomal protein L37 pseudogene Neighboring gene uncharacterized LOC105369392 Neighboring gene monoacylglycerol O-acyltransferase 2 Neighboring gene uncharacterized LOC105369393

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41346, KIAA1878

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lysosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi-associated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
microtubule-associated protein 6
Names
CTD-2530H12.7
MAP-6
stable tubule-only polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052841.1 RefSeqGene

    Range
    7675..89191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_033063.1NP_149052.1  microtubule-associated protein 6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AB058781, AK123340, BC063860
    Consensus CDS
    CCDS31641.1
    UniProtKB/Swiss-Prot
    Q96JE9
    Related
    ENSP00000307093.3, OTTHUMP00000229411, ENST00000304771.7, OTTHUMT00000383527
    Conserved Domains (1) summary
    pfam05217
    Location:298406
    STOP; STOP protein
  2. NM_207577.1NP_997460.1  microtubule-associated protein 6 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different 3' coding region compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB058781, BC041411, BC063860
    Consensus CDS
    CCDS44686.1
    UniProtKB/Swiss-Prot
    Q96JE9
    Related
    ENSP00000415108.2, OTTHUMP00000229418, ENST00000434603.2, OTTHUMT00000383541
    Conserved Domains (1) summary
    pfam05217
    Location:298406
    STOP; STOP protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    75586914..75668724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017755.2XP_016873244.1  microtubule-associated protein 6 isoform X1

  2. XM_017017757.1XP_016873246.1  microtubule-associated protein 6 isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:188503
    PHA03247; large tegument protein UL36; Provisional
    COG5269
    Location:4178
    ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
  3. XM_017017756.1XP_016873245.1  microtubule-associated protein 6 isoform X2

  4. XM_017017758.1XP_016873247.1  microtubule-associated protein 6 isoform X4

    Related
    ENSP00000434278.1, OTTHUMP00000229417, ENST00000526740.3, OTTHUMT00000383538
  5. XM_006718556.4XP_006718619.1  microtubule-associated protein 6 isoform X6

    Conserved Domains (1) summary
    pfam05217
    Location:298354
    STOP; STOP protein
  6. XM_011545039.3XP_011543341.1  microtubule-associated protein 6 isoform X5

    Conserved Domains (1) summary
    pfam05217
    Location:298354
    STOP; STOP protein

RNA

  1. XR_949931.3 RNA Sequence

  2. XR_949933.3 RNA Sequence

  3. XR_949932.3 RNA Sequence

Support Center