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Map6 microtubule-associated protein 6 [ Mus musculus (house mouse) ]

Gene ID: 17760, updated on 8-Jan-2023

Summary

Official Symbol
Map6provided by MGI
Official Full Name
microtubule-associated protein 6provided by MGI
Primary source
MGI:MGI:1201690
See related
Ensembl:ENSMUSG00000055407 AllianceGenome:MGI:1201690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
STOP; Map-6; Mtap6; 2810411E12Rik
Summary
Enables microtubule binding activity. Predicted to be involved in several processes, including axonal transport of mitochondrion; generation of neurons; and lysosome localization. Predicted to be located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and secretory vesicle. Predicted to be active in several cellular components, including Golgi-associated vesicle; cis-Golgi network; and microtubule. Is expressed in cranial ganglion; dorsal root ganglion; and sensory organ. Used to study schizophrenia. Orthologous to human MAP6 (microtubule associated protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 17.6), whole brain E14.5 (RPKM 16.8) and 9 other tissues See more
Orthologs
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Genomic context

See Map6 in Genome Data Viewer
Location:
7; 7 E1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (98916270..98986344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99266779..99337137)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene WW domain containing adaptor with coiled-coil pseudogene Neighboring gene predicted gene, 34062 Neighboring gene predicted gene, 26705 Neighboring gene predicted gene, 40449 Neighboring gene serine (or cysteine) peptidase inhibitor, clade H, member 1 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in axonal transport of mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in Golgi-associated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in secretory vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
microtubule-associated protein 6
Names
stable tubule-only polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001043355.2NP_001036820.2  microtubule-associated protein 6 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' coding region, uses a downstream, in-frame start codon as described in PubMed: 14567673, and lacks an alternate exon in the 3' coding region that results in a frameshift, compared to variant 1. These differences result in a shorter protein (isoform 3, also known as F-STOP) with shorter and distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC111120, AC158748
    Consensus CDS
    CCDS40029.1
    UniProtKB/Swiss-Prot
    Q7TSJ2
    Related
    ENSMUSP00000102717.3, ENSMUST00000107100.3
    Conserved Domains (1) summary
    pfam05217
    Location:224281
    STOP; STOP protein
  2. NM_001048167.1NP_001041632.1  microtubule-associated protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001041632.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant(2) lacks an alternate in-frame exon in the 3' coding region and differs in the 3' UTR, compared to variant 1. This results in a shorter protein (isoform 2, also known as E-STOP) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC111120, AC158748
    Consensus CDS
    CCDS85345.1
    UniProtKB/Swiss-Prot
    Q7TSJ2
    Related
    ENSMUSP00000146340.2, ENSMUST00000127492.2
    Conserved Domains (1) summary
    pfam05217
    Location:427521
    STOP; STOP protein
  3. NM_010837.3NP_034967.2  microtubule-associated protein 6 isoform 1

    See identical proteins and their annotated locations for NP_034967.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1), also known as N-STOP.
    Source sequence(s)
    AK018193, AK087413, BE951502, BE980868, BQ444318
    Consensus CDS
    CCDS21479.1
    UniProtKB/Swiss-Prot
    Q78DV5, Q7TSJ2
    Related
    ENSMUSP00000146585.2, ENSMUST00000207883.2
    Conserved Domains (1) summary
    pfam05217
    Location:117185
    STOP; STOP protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    98916270..98986344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003946412.2 RNA Sequence

  2. XR_869665.4 RNA Sequence

  3. XR_378220.5 RNA Sequence

  4. XR_869667.4 RNA Sequence

  5. XR_004934030.1 RNA Sequence

  6. XR_003946413.2 RNA Sequence

  7. XR_004934029.1 RNA Sequence

  8. XR_004934033.1 RNA Sequence

  9. XR_004934031.1 RNA Sequence

  10. XR_004934032.1 RNA Sequence