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MAP1A microtubule associated protein 1A [ Homo sapiens (human) ]

Gene ID: 4130, updated on 2-Oct-2018

Summary

Official Symbol
MAP1Aprovided by HGNC
Official Full Name
microtubule associated protein 1Aprovided by HGNC
Primary source
HGNC:HGNC:6835
See related
Ensembl:ENSG00000166963 MIM:600178; Vega:OTTHUMG00000059756
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP1L; MTAP1A
Summary
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 73.0), heart (RPKM 5.9) and 1 other tissue See more
Orthologs

Genomic context

See MAP1A in Genome Data Viewer
Location:
15q15.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (43517608..43531620)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43803165..43823818)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex associated protein 4 Neighboring gene RNA, 7SL, cytoplasmic 487, pseudogene Neighboring gene tumor protein p53 binding protein 1 Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene creatine kinase, mitochondrial 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of MAP1A by shRNA inhibits HIV-1 infectivity in human PBMCs PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag MAP1A and MAP1S proteins activate HIV-1 retrograde trafficking by tethering capsids to microtubules in primary human macrophages PubMed
gag MAP1A and MAP1S depletion leads to an accumulation of HIV-1 CA labelling throughout the cytoplasm, suggesting an inability both to reach the nuclear membrane and to uncoat PubMed
gag MAP1A and MAP1S proteins interact with HIV-1 CA cores in primary human macrophages PubMed
retropepsin gag-pol HIV-1 protease extensively cleaves microtubule-associated proteins 1 and 2 and completely inhibits microtubule assembly PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ77111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeletal adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
anterograde axonal protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
associative learning ISS
Inferred from Sequence or Structural Similarity
more info
 
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
memory ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein localization to microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cellular protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein localization to cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
retrograde axonal protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
voluntary musculoskeletal movement ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
axon initial segment ISS
Inferred from Sequence or Structural Similarity
more info
 
cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic branch ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
primary dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
microtubule-associated protein 1A
Names
MAP-1A
proliferation-related protein p80

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002373.5NP_002364.5  microtubule-associated protein 1A

    See identical proteins and their annotated locations for NP_002364.5

    Status: REVIEWED

    Source sequence(s)
    AC019011, AI124707, BC094702, BP309709
    Consensus CDS
    CCDS42031.1
    UniProtKB/Swiss-Prot
    P78559
    UniProtKB/TrEMBL
    Q504X9
    Related
    ENSP00000300231.5, OTTHUMP00000196074, ENST00000300231.5, OTTHUMT00000132894
    Conserved Domains (4) summary
    pfam12718
    Location:13971540
    Tropomyosin_1; Tropomyosin like
    cd16269
    Location:14561470
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:13641488
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23716
    Location:50101
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    43517608..43531620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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