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MAP1A microtubule associated protein 1A [ Homo sapiens (human) ]

Gene ID: 4130, updated on 3-Nov-2024

Summary

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Official Symbol
MAP1Aprovided by HGNC
Official Full Name
microtubule associated protein 1Aprovided by HGNC
Primary source
HGNC:HGNC:6835
See related
Ensembl:ENSG00000166963 MIM:600178; AllianceGenome:HGNC:6835
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP1L; MTAP1A
Summary
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 73.0), heart (RPKM 5.9) and 1 other tissue See more
Orthologs
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Genomic context

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See MAP1A in Genome Data Viewer
Location:
15q15.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (43510954..43531611)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (41318305..41338962)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43803152..43823809)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex component 4 Neighboring gene RNA, 7SL, cytoplasmic 487, pseudogene Neighboring gene tumor protein p53 binding protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:43734212-43734815 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:43769402-43769643 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:43784380-43785088 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:43785089-43785795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43787292-43787792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43810281-43810924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43819912-43820544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43821526-43822026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43822027-43822527 Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene creatine kinase, mitochondrial 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Similar ultrastructural distribution of the 5-HT(2A) serotonin receptor and microtubule-associated protein MAP1A in cortical dendrites of adult rat. Cornea-Hébert V, et al. Neuroscience, 2002. PMID 12123681
  2. Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants. Satterstrom FK, et al. Nat Neurosci, 2019 Dec. PMID 31768057, Free PMC Article
  3. Widespread cellular distribution of MAP-1A (microtubule-associated protein 1A) in the mitotic spindle and on interphase microtubules. Bloom GS, et al. J Cell Biol, 1984 Jan. PMID 6142895, Free PMC Article
  4. Expression of MAP1a and MAP1b in the ganglionic eminence and the internal capsule of the human fetal brain. Ulfig N, et al. Neurosci Res, 2000 Dec. PMID 11164566
  5. Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15. Fukuyama R, et al. J Neurosci Res, 1995 Apr 15. PMID 7629894

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis across Autism Spectrum Disorder and Attention Defecit Hyperactivity Disorder, identifyies microtubule-associated protein 1A (MAP1A) as a new exome-wide significant gene conferring risk for childhood psychiatric disorders.
    Title: Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants.
  2. MAP1A functions to maintain the neuronal microtubule network in the brain and mutations cause Purkinje cell degeneration.
    Title: Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration.
  3. results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules.
    Title: Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.
  4. This protein has been found differentially expressed in thalami from patients with schizophrenia.
    Title: Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.
  6. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
    Title: Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
  7. postulate that the RhoB and MAP1A/LC2 interactions facilitate endocytic vesicle trafficking and regulate the trafficking of signaling molecules
    Title: MAP1A light chain-2 interacts with GTP-RhoB to control epidermal growth factor (EGF)-dependent EGF receptor signaling.
  8. MAP1A LC2 is a biological enhancer of EPAC1 activity toward Rap1 and associated downstream signaling mechanisms
    Title: MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion.
  9. Complexes (MAP1B heavy chain-MAP1A light chain) form through interaction of homologous domains conserved in heavy and light chains of MAP1A and MAP1B. Conserved domains of the MAP1A and MAP1B light chains account for formation of light chain heterodimers.
    Title: Heterotypic complex formation between subunits of microtubule-associated proteins 1A and 1B is due to interaction of conserved domains.
  10. Data show that two regulatory factor for X box (RFX1 and 3) binding sites in exon1 of both the mouse and human microtubule-associated protein (MAP1A) gene are important for effective transcriptional repression in non-neuronal cells.
    Title: Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of MAP1A by shRNA inhibits HIV-1 infectivity in human PBMCs PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag MAP1A and MAP1S proteins activate HIV-1 retrograde trafficking by tethering capsids to microtubules in primary human macrophages PubMed
gag MAP1A and MAP1S depletion leads to an accumulation of HIV-1 CA labelling throughout the cytoplasm, suggesting an inability both to reach the nuclear membrane and to uncoat PubMed
gag MAP1A and MAP1S proteins interact with HIV-1 CA cores in primary human macrophages PubMed
retropepsin gag-pol HIV-1 protease extensively cleaves microtubule-associated proteins 1 and 2 and completely inhibits microtubule assembly PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ77111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cytoskeletal anchor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables microtubule binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables tau protein binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in associative learning ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in memory ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein localization to microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein localization to cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde axonal protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in voluntary musculoskeletal movement ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in axon initial segment ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic branch ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in primary dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
microtubule-associated protein 1A
Names
MAP-1A
proliferation-related protein p80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411089.1 → NP_001398018.1  microtubule-associated protein 1A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC018924, AC019011
    Consensus CDS
    CCDS91988.1
    UniProtKB/TrEMBL
    E9PGC8
    Related
    ENSP00000371462.1, ENST00000382031.5

  2. NM_002373.6 → NP_002364.5  microtubule-associated protein 1A isoform 1

    See identical proteins and their annotated locations for NP_002364.5

    Status: REVIEWED

    Source sequence(s)
    AC019011, AI124707, BC094702, BP309709
    Consensus CDS
    CCDS42031.1
    UniProtKB/Swiss-Prot
    O95643, P78559, Q12973, Q15882, Q9UJT4
    Related
    ENSP00000300231.5, ENST00000300231.6
    Conserved Domains (4) summary
    pfam12718
    Location:1397 → 1540
    Tropomyosin_1; Tropomyosin like
    cd16269
    Location:1456 → 1470
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:1364 → 1488
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23716
    Location:50 → 101
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    43510954..43531611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    41318305..41338962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P78559.6 GenPept UniProtKB/Swiss-Prot:P78559

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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