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MAOB monoamine oxidase B [ Homo sapiens (human) ]

Gene ID: 4129, updated on 7-Dec-2018

Summary

Official Symbol
MAOBprovided by HGNC
Official Full Name
monoamine oxidase Bprovided by HGNC
Primary source
HGNC:HGNC:6834
See related
Ensembl:ENSG00000069535 MIM:309860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
Expression
Broad expression in liver (RPKM 72.6), ovary (RPKM 62.8) and 18 other tissues See more
Orthologs

Genomic context

See MAOB in Genome Data Viewer
Location:
Xp11.3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (43766610..43882475, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (43625857..43741721, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Nanog homeobox pseudogene 10 Neighboring gene monoamine oxidase A Neighboring gene NDP antisense RNA 1 Neighboring gene NDP, norrin cystine knot growth factor Neighboring gene RNA binding motif protein 39 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26382

Gene Ontology Provided by GOA

Function Evidence Code Pubs
electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
primary amine oxidase activity TAS
Traceable Author Statement
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
dopamine catabolic process TAS
Traceable Author Statement
more info
PubMed 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of serotonin secretion IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
response to aluminum ion IEA
Inferred from Electronic Annotation
more info
 
response to corticosterone IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to selenium ion IEA
Inferred from Electronic Annotation
more info
 
substantia nigra development HEP PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial envelope TAS
Traceable Author Statement
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
PubMed 
mitochondrion HDA PubMed 

General protein information

Preferred Names
amine oxidase [flavin-containing] B
Names
MAO, brain
MAO, platelet
MAO-B
adrenalin oxidase
monoamine oxidase type B
tyramine oxidase
NP_000889.3
XP_005272665.1
XP_016885012.1
XP_016885013.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008723.2 RefSeqGene

    Range
    5001..120866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000898.5NP_000889.3  amine oxidase [flavin-containing] B

    See identical proteins and their annotated locations for NP_000889.3

    Status: REVIEWED

    Source sequence(s)
    AL133791, BM726427, DC326844, M69177
    Consensus CDS
    CCDS14261.1
    UniProtKB/Swiss-Prot
    P27338
    Related
    ENSP00000367309.4, ENST00000378069.4
    Conserved Domains (1) summary
    pfam01593
    Location:14451
    Amino_oxidase; Flavin containing amine oxidoreductase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    43766610..43882475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272608.3XP_005272665.1  amine oxidase [flavin-containing] B isoform X1

    See identical proteins and their annotated locations for XP_005272665.1

    UniProtKB/TrEMBL
    B7Z242
    Conserved Domains (2) summary
    pfam01593
    Location:1435
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:159
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. XM_017029523.1XP_016885012.1  amine oxidase [flavin-containing] B isoform X1

    UniProtKB/TrEMBL
    B7Z242
    Conserved Domains (2) summary
    pfam01593
    Location:1435
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:159
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. XM_017029524.2XP_016885013.1  amine oxidase [flavin-containing] B isoform X1

    UniProtKB/TrEMBL
    B7Z242
    Conserved Domains (2) summary
    pfam01593
    Location:1435
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:159
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
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