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Maob monoamine oxidase B [ Mus musculus (house mouse) ]

Gene ID: 109731, updated on 6-Oct-2024

Summary

Official Symbol
Maobprovided by MGI
Official Full Name
monoamine oxidase Bprovided by MGI
Primary source
MGI:MGI:96916
See related
Ensembl:ENSMUSG00000040147 AllianceGenome:MGI:96916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MAO-B; 6330414K01Rik
Summary
Predicted to enable flavin adenine dinucleotide binding activity; identical protein binding activity; and primary amine oxidase activity. Predicted to be involved in negative regulation of serotonin secretion; neurotransmitter catabolic process; and positive regulation of dopamine metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human MAOB (monoamine oxidase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 125.6), liver adult (RPKM 44.7) and 11 other tissues See more
Orthologs
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Genomic context

See Maob in Genome Data Viewer
Location:
X A1.2; X 11.88 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (16575520..16683605, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (16709281..16817366, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene casein kinase 2, alpha 1 polypeptide, pseudogene 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:16196670-16196853 Neighboring gene monoamine oxidase A Neighboring gene STARR-seq mESC enhancer starr_46819 Neighboring gene STARR-seq mESC enhancer starr_46820 Neighboring gene Norrie disease (pseudoglioma) (human) Neighboring gene STARR-seq mESC enhancer starr_46821 Neighboring gene STARR-seq mESC enhancer starr_46822 Neighboring gene predicted gene 4203

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aliphatic amine oxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables monoamine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables monoamine oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables primary methylamine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables primary methylamine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables primary methylamine oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in negative regulation of serotonin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of serotonin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in phenylethylamine catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phenylethylamine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to aluminum ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to corticosterone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to selenium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to steroid hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
amine oxidase [flavin-containing] B
Names
monoamine oxidase type B
NP_766366.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172778.2NP_766366.2  amine oxidase [flavin-containing] B

    See identical proteins and their annotated locations for NP_766366.2

    Status: VALIDATED

    Source sequence(s)
    AK031833, AK054050, BE943751, BY257414
    Consensus CDS
    CCDS40882.1
    UniProtKB/Swiss-Prot
    Q14CG9, Q8BW75, Q8C0B2
    Related
    ENSMUSP00000040550.7, ENSMUST00000040820.13
    Conserved Domains (2) summary
    pfam01593
    Location:14451
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:975
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    16575520..16683605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)