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MAGEA5P MAGE family member A5, pseudogene [ Homo sapiens (human) ]

Gene ID: 4104, updated on 24-Jul-2021

Summary

Official Symbol
MAGEA5Pprovided by HGNC
Official Full Name
MAGE family member A5, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:6803
See related
MIM:300340
Gene type
pseudo
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT1.5; MAGE5; MAGEA4; MAGEA5
Summary
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This MAGEA gene is interpreted to be a pseudogene. Read-through transcription exists between this gene and the upstream melanoma antigen family A, 10 (MAGEA10) gene. [provided by RefSeq, Dec 2020]
Expression
Low expression observed in reference dataset See more
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Genomic context

See MAGEA5P in Genome Data Viewer
Location:
Xq28
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (152114049..152117939, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151282521..151286411, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373369 Neighboring gene gamma-aminobutyric acid type A receptor subunit epsilon Neighboring gene microRNA 452 Neighboring gene ribosomal protein SA pseudogene 60 Neighboring gene MAGEA10-MAGEA5 readthrough Neighboring gene MAGE family member A10 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha3 Neighboring gene RNA, U6 small nuclear 764, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Markers

Readthrough MAGEA10-MAGEA5

Readthrough gene: MAGEA10-MAGEA5, Included gene: MAGEA10

Other Names

  • MAGE family member A5
  • MAGE-5 antigen
  • MAGE-5a antigen
  • MAGE-5b antigen
  • cancer/testis antigen 1.5
  • cancer/testis antigen family 1, member 5
  • melanoma antigen family A, 5
  • melanoma antigen family A5
  • melanoma-associated antigen 5

Clone Names

  • MGC129526

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_171383.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF274856

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    152114049..152117939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_016417.1: Suppressed sequence

    Description
    NG_016417.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
  2. NM_021049.4: Suppressed sequence

    Description
    NM_021049.4: This RefSeq was removed because it is now thought that this gene is a pseudogene.
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