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MAGEA10 MAGE family member A10 [ Homo sapiens (human) ]

Gene ID: 4109, updated on 5-Aug-2022

Summary

Official Symbol
MAGEA10provided by HGNC
Official Full Name
MAGE family member A10provided by HGNC
Primary source
HGNC:HGNC:6797
See related
Ensembl:ENSG00000124260 MIM:300343; AllianceGenome:HGNC:6797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT1.10; MAGE10
Summary
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011]
Expression
Biased expression in placenta (RPKM 4.9) and testis (RPKM 1.2) See more
Orthologs
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Genomic context

See MAGEA10 in Genome Data Viewer
Location:
Xq28
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (152133310..152138577, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (150399374..150404642, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151301782..151307049, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 60 Neighboring gene uncharacterized LOC105373369 Neighboring gene MAGEA10-MAGEA5 readthrough Neighboring gene MAGE family member A5, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4725 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha3 Neighboring gene RNA, U6 small nuclear 764, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10599

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
melanoma-associated antigen 10
Names
MAGE-10 antigen
cancer/testis antigen 1.10
cancer/testis antigen family 1, member 10
melanoma antigen family A, 10
melanoma antigen family A10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011543.3NP_001011543.3  melanoma-associated antigen 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC116666
    Consensus CDS
    CCDS14705.1
    UniProtKB/Swiss-Prot
    P43363
    Related
    ENSP00000244096.3, ENST00000244096.7
    Conserved Domains (2) summary
    pfam01454
    Location:141306
    MAGE; MAGE family
    pfam12440
    Location:6116
    MAGE_N; Melanoma associated antigen family N terminal
  2. NM_001251828.2NP_001238757.2  melanoma-associated antigen 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC116666
    Consensus CDS
    CCDS14705.1
    UniProtKB/Swiss-Prot
    P43363
    Conserved Domains (2) summary
    pfam01454
    Location:141306
    MAGE; MAGE family
    pfam12440
    Location:6116
    MAGE_N; Melanoma associated antigen family N terminal
  3. NM_021048.5NP_066386.3  melanoma-associated antigen 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC116666
    Consensus CDS
    CCDS14705.1
    UniProtKB/Swiss-Prot
    P43363
    Related
    ENSP00000359347.4, ENST00000370323.9
    Conserved Domains (2) summary
    pfam01454
    Location:141306
    MAGE; MAGE family
    pfam12440
    Location:6116
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    152133310..152138577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    150399374..150404642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)