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MAGEA3 MAGE family member A3 [ Homo sapiens (human) ]

Gene ID: 4102, updated on 24-Nov-2020

Summary

Official Symbol
MAGEA3provided by HGNC
Official Full Name
MAGE family member A3provided by HGNC
Primary source
HGNC:HGNC:6801
See related
Ensembl:ENSG00000221867 MIM:300174
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIP8; HYPD; CT1.3; MAGE3; MAGEA6
Summary
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 4.8) See more
Orthologs

Genomic context

See MAGEA3 in Genome Data Viewer
Location:
Xq28
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (152698742..152702347)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151934652..151938250, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373370 Neighboring gene gamma-aminobutyric acid type A receptor subunit theta Neighboring gene MAGE family member A4 pseudogene Neighboring gene CSAG family member 2 Neighboring gene MAGE family member A2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of melanoma antigen family A, 3 (MAGEA3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14613

Gene Ontology Provided by GOA

Function Evidence Code Pubs
caspase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
melanoma-associated antigen 3
Names
MAGE-3 antigen
antigen MZ2-D
cancer/testis antigen 1.3
cancer/testis antigen family 1, member 3
melanoma antigen family A, 3
melanoma antigen family A3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013244.1 RefSeqGene

    Range
    5043..8589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005362.4NP_005353.1  melanoma-associated antigen 3

    See identical proteins and their annotated locations for NP_005353.1

    Status: REVIEWED

    Source sequence(s)
    AC244102
    Consensus CDS
    CCDS76045.1
    UniProtKB/Swiss-Prot
    P43357
    Related
    ENSP00000359301.3, ENST00000370278.4
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    152698742..152702347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274676.3XP_005274733.1  melanoma-associated antigen 3 isoform X1

    See identical proteins and their annotated locations for XP_005274733.1

    UniProtKB/Swiss-Prot
    P43357
    Related
    ENSP00000473093.1, ENST00000598245.2
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  2. XM_011531160.3XP_011529462.1  melanoma-associated antigen 3 isoform X1

    See identical proteins and their annotated locations for XP_011529462.1

    UniProtKB/Swiss-Prot
    P43357
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  3. XM_006724818.2XP_006724881.1  melanoma-associated antigen 3 isoform X1

    See identical proteins and their annotated locations for XP_006724881.1

    UniProtKB/Swiss-Prot
    P43357
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
  4. XM_011531161.2XP_011529463.1  melanoma-associated antigen 3 isoform X1

    See identical proteins and their annotated locations for XP_011529463.1

    UniProtKB/Swiss-Prot
    P43357
    Conserved Domains (2) summary
    pfam01454
    Location:116280
    MAGE; MAGE family
    pfam12440
    Location:594
    MAGE_N; Melanoma associated antigen family N terminal
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