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ARRB2 arrestin beta 2 [ Homo sapiens (human) ]

Gene ID: 409, updated on 24-Nov-2020

Summary

Official Symbol
ARRB2provided by HGNC
Official Full Name
arrestin beta 2provided by HGNC
Primary source
HGNC:HGNC:712
See related
Ensembl:ENSG00000141480 MIM:107941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARB2; ARR2; BARR2
Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Expression
Broad expression in bone marrow (RPKM 69.2), appendix (RPKM 43.9) and 21 other tissues See more
Orthologs

Genomic context

See ARRB2 in Genome Data Viewer
Location:
17p13.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (4710619..4721500)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4613789..4624795)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene uncharacterized LOC101559451 Neighboring gene ribosomal protein S12 pseudogene 29 Neighboring gene mediator complex subunit 11 Neighboring gene C-X-C motif chemokine ligand 16 Neighboring gene zinc finger MYND-type containing 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with arrestin, beta 2 (ARRB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat Overexpression of HIV-1 Tat results in a nonspecific activation of the expression of beta-arrestin PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with arrestin, beta 2 (ARRB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686L0365

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IEA
Inferred from Electronic Annotation
more info
 
D1 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
alpha-1A adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
 
alpha-1B adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
 
angiotensin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiotensin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
arrestin family protein binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
follicle-stimulating hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
molecular adaptor activity IDA
Inferred from Direct Assay
more info
 
platelet activating factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase B binding IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
type 1 angiotensin receptor binding IEA
Inferred from Electronic Annotation
more info
 
type 2A serotonin receptor binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor internalization TAS
Traceable Author Statement
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
 
adult walking behavior IEA
Inferred from Electronic Annotation
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
desensitization of G protein-coupled receptor signaling pathway by arrestin IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of temperature stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
dopamine receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
excitatory postsynaptic potential NAS
Non-traceable Author Statement
more info
PubMed 
follicle-stimulating hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
negative regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase B signaling NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein ubiquitination IGI
Inferred from Genetic Interaction
more info
 
positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endosome IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-arrestin-2
Names
arrestin 3
non-visual arrestin-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257328.2NP_001244257.1  beta-arrestin-2 isoform 3

    See identical proteins and their annotated locations for NP_001244257.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AB209786, AK297181, BC007427, BG723452
    Consensus CDS
    CCDS58504.1
    UniProtKB/Swiss-Prot
    P32121
    UniProtKB/TrEMBL
    Q59EM5
    Related
    ENSP00000403701.3, ENST00000412477.7
    Conserved Domains (2) summary
    smart01017
    Location:215370
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:19196
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. NM_001257329.2NP_001244258.1  beta-arrestin-2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 3' end of an exon and uses an alternate splice junction at the 3' end of another exon, that causes a frameshift. The resulting isoform (4) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 3.
    Source sequence(s)
    BC007427, BC095450, BG723452
    Consensus CDS
    CCDS59276.1
    UniProtKB/Swiss-Prot
    P32121
    UniProtKB/TrEMBL
    K7ENA6
    Related
    ENSP00000466857.1, ENST00000575877.5
    Conserved Domains (2) summary
    smart01017
    Location:194264
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:19175
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  3. NM_001257330.2NP_001244259.1  beta-arrestin-2 isoform 5

    See identical proteins and their annotated locations for NP_001244259.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 3' end of an exon and uses an alternate in-frame splice junction at the 5' end of another exon compared to variant 3. The resulting isoform (5) lacks an alternate internal segment and contains another alternate internal segment compared to isoform 3.
    Source sequence(s)
    BC007427, BG723452, DQ664180
    UniProtKB/Swiss-Prot
    P32121
    Conserved Domains (2) summary
    smart01017
    Location:194349
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:19175
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  4. NM_001257331.2NP_001244260.1  beta-arrestin-2 isoform 6

    See identical proteins and their annotated locations for NP_001244260.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon, uses an alternate in-frame splice junction at the 3' end of an exon, and uses an alternate in-frame splice junction at the 5' end of another exon compared to variant 3. The resulting isoform (6) lacks two alternate internal segments and contains another alternate internal segment compared to isoform 3.
    Source sequence(s)
    AK097542, BC007427, BG723452, DQ664180
    Consensus CDS
    CCDS58505.1
    UniProtKB/Swiss-Prot
    P32121
    Related
    ENSP00000341895.2, ENST00000346341.6
    Conserved Domains (2) summary
    smart01017
    Location:179334
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:19160
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  5. NM_001330064.2NP_001316993.1  beta-arrestin-2 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has multiple differences compared to variant 3. The encoded isoform (7) is shorter than isoform 3.
    Source sequence(s)
    AC091153, BC007427
    Consensus CDS
    CCDS82039.1
    UniProtKB/Swiss-Prot
    P32121
    UniProtKB/TrEMBL
    Q68DZ5
    Related
    ENSP00000465296.1, ENST00000572457.5
    Conserved Domains (1) summary
    smart01017
    Location:2157
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
  6. NM_004313.4NP_004304.1  beta-arrestin-2 isoform 1

    See identical proteins and their annotated locations for NP_004304.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 3. The resulting isoform (1) lacks an alternate internal segment compared to isoform 3.
    Source sequence(s)
    AF106941, BC007427, BG723452
    Consensus CDS
    CCDS11050.1
    UniProtKB/Swiss-Prot
    P32121
    Related
    ENSP00000269260.2, ENST00000269260.7
    Conserved Domains (2) summary
    smart01017
    Location:194349
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:19175
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  7. NM_199004.2NP_945355.1  beta-arrestin-2 isoform 2

    See identical proteins and their annotated locations for NP_945355.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 3' end of another exon compared to variant 3. The resulting isoform (2) lacks two alternate internal segments compared to isoform 3.
    Source sequence(s)
    AF106941, AK097542, BC007427, BG723452
    Consensus CDS
    CCDS11051.1
    UniProtKB/Swiss-Prot
    P32121
    Related
    ENSP00000370898.6, ENST00000381488.10
    Conserved Domains (2) summary
    smart01017
    Location:179334
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:19160
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RNA

  1. NR_047516.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an alternate coding exon compared to isoform 3, that causes a frameshift. The resulting transcript could encode a 217 aa isoform but instead is thought to be non-protein coding due to the presence of an upstream open reading frame with a strong Kozak signal. Translation beginning at that start site renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB209786, BC007427, BG723452

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    4710619..4721500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450752.1XP_024306520.1  beta-arrestin-2 isoform X3

    Conserved Domains (1) summary
    smart01017
    Location:2157
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
  2. XM_024450751.1XP_024306519.1  beta-arrestin-2 isoform X2

    Conserved Domains (2) summary
    smart01017
    Location:194349
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:19175
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  3. XM_024450753.1XP_024306521.1  beta-arrestin-2 isoform X3

    Conserved Domains (1) summary
    smart01017
    Location:2157
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
  4. XM_011523858.2XP_011522160.1  beta-arrestin-2 isoform X1

    Conserved Domains (2) summary
    smart01017
    Location:225380
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:50206
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  5. XM_017024645.1XP_016880134.1  beta-arrestin-2 isoform X3

    Conserved Domains (1) summary
    smart01017
    Location:2157
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain

RNA

  1. XR_002958007.1 RNA Sequence

  2. XR_002958006.1 RNA Sequence

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