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Cpa5 carboxypeptidase A5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 408212, updated on 17-Aug-2024

Summary

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Symbol
Cpa5provided by RGD
Full Name
carboxypeptidase A5provided by RGD
Primary source
RGD:1303098
See related
EnsemblRapid:ENSRNOG00000010467 AllianceGenome:RGD:1303098
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Orthologous to human CPA5 (carboxypeptidase A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 86.5) See more
Orthologs
human mouse all
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Genomic context

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Location:
4q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (60197123..60216883)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (59229754..59249503)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57925334..57945069)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102251 Neighboring gene carboxypeptidase A2 Neighboring gene carboxypeptidase A4 Neighboring gene uncharacterized LOC102553416 Neighboring gene carboxypeptidase A1 Neighboring gene centrosomal protein 41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. Wei S, et al. J Biol Chem, 2002 Apr 26. PMID 11836249
  2. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC94525

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carboxypeptidase A5
NP_001002808.2
XP_006236278.1
XP_006236279.1
XP_006236280.1
XP_038963901.1
XP_038963903.1
XP_063142482.1
XP_063142483.1
XP_063142484.1
XP_063142485.1
XP_063142486.1
XP_063142487.1
XP_063142488.1
XP_063142489.1
XP_063142490.1
XP_063142491.1
XP_063142492.1
XP_063142493.1
XP_063142494.1
XP_063142495.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002808.2 → NP_001002808.2  carboxypeptidase A5

    See identical proteins and their annotated locations for NP_001002808.2

    Status: PROVISIONAL

    Source sequence(s)
    BC085840
    UniProtKB/TrEMBL
    E9PSV1, Q5U2W3, Q6IE16
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    60197123..60216883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236216.5 → XP_006236278.1  carboxypeptidase A5 isoform X2

    See identical proteins and their annotated locations for XP_006236278.1

    UniProtKB/TrEMBL
    E9PSV1, Q5U2W3, Q6IE16
    Related
    ENSRNOP00000013948.4, ENSRNOT00000013948.7
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  2. XM_039107973.2 → XP_038963901.1  carboxypeptidase A5 isoform X4

    UniProtKB/TrEMBL
    Q6IE16
    Conserved Domains (2) summary
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134 → 374
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

  3. XM_006236217.5 → XP_006236279.1  carboxypeptidase A5 isoform X2

    See identical proteins and their annotated locations for XP_006236279.1

    UniProtKB/TrEMBL
    E9PSV1, Q5U2W3, Q6IE16
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  4. XM_006236218.5 → XP_006236280.1  carboxypeptidase A5 isoform X2

    See identical proteins and their annotated locations for XP_006236280.1

    UniProtKB/TrEMBL
    E9PSV1, Q5U2W3, Q6IE16
    Conserved Domains (2) summary
    cd03870
    Location:134 → 434
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide

  5. XM_063286422.1 → XP_063142492.1  carboxypeptidase A5 isoform X4

    UniProtKB/TrEMBL
    Q6IE16

  6. XM_063286412.1 → XP_063142482.1  carboxypeptidase A5 isoform X1

    UniProtKB/TrEMBL
    Q6IE16

  7. XM_063286415.1 → XP_063142485.1  carboxypeptidase A5 isoform X1

    UniProtKB/TrEMBL
    Q6IE16

  8. XM_039107975.2 → XP_038963903.1  carboxypeptidase A5 isoform X7

    Conserved Domains (2) summary
    pfam02244
    Location:48 → 117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134 → 280
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

  9. XM_063286419.1 → XP_063142489.1  carboxypeptidase A5 isoform X3

    UniProtKB/TrEMBL
    Q6IE16

  10. XM_063286418.1 → XP_063142488.1  carboxypeptidase A5 isoform X3

    UniProtKB/TrEMBL
    Q6IE16

  11. XM_063286413.1 → XP_063142483.1  carboxypeptidase A5 isoform X1

    UniProtKB/TrEMBL
    Q6IE16

  12. XM_063286420.1 → XP_063142490.1  carboxypeptidase A5 isoform X4

    UniProtKB/TrEMBL
    Q6IE16

  13. XM_063286416.1 → XP_063142486.1  carboxypeptidase A5 isoform X1

    UniProtKB/TrEMBL
    Q6IE16

  14. XM_063286417.1 → XP_063142487.1  carboxypeptidase A5 isoform X2

    UniProtKB/TrEMBL
    E9PSV1, Q5U2W3, Q6IE16

  15. XM_063286423.1 → XP_063142493.1  carboxypeptidase A5 isoform X5

  16. XM_063286421.1 → XP_063142491.1  carboxypeptidase A5 isoform X4

    UniProtKB/TrEMBL
    Q6IE16

  17. XM_063286414.1 → XP_063142484.1  carboxypeptidase A5 isoform X1

    UniProtKB/TrEMBL
    Q6IE16

  18. XM_063286425.1 → XP_063142495.1  carboxypeptidase A5 isoform X6

    UniProtKB/TrEMBL
    Q6IE16

  19. XM_063286424.1 → XP_063142494.1  carboxypeptidase A5 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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