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CPA5 carboxypeptidase A5 [ Homo sapiens (human) ]

Gene ID: 93979, updated on 1-Jun-2020

Summary

Official Symbol
CPA5provided by HGNC
Official Full Name
carboxypeptidase A5provided by HGNC
Primary source
HGNC:HGNC:15722
See related
Ensembl:ENSG00000158525 MIM:609561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]
Expression
Restricted expression toward testis (RPKM 7.8) See more
Orthologs

Genomic context

See CPA5 in Genome Data Viewer
Location:
7q32.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (130344791..130368730)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129984630..130008571)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5425 Neighboring gene carboxypeptidase A2 Neighboring gene carboxypeptidase A4 Neighboring gene uncharacterized LOC105375503 Neighboring gene uncharacterized LOC105375504 Neighboring gene carboxypeptidase A1 Neighboring gene centrosomal protein 41

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ35969

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carboxypeptidase A5
Names
testicular tissue protein Li 32
NP_001120913.1
NP_001120914.1
NP_001305152.1
NP_525124.3
XP_005250767.1
XP_005250769.1
XP_011515000.1
XP_011515003.1
XP_011515004.1
XP_011515005.1
XP_011515006.1
XP_011515007.1
XP_024302767.1
XP_024302768.1
XP_024302769.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127441.2NP_001120913.1  carboxypeptidase A5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001120913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same isoform (1).
    Source sequence(s)
    BC039362, BC053681, BK000187, KF495711
    Consensus CDS
    CCDS5819.1
    UniProtKB/Swiss-Prot
    Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2
    Conserved Domains (2) summary
    pfam02244
    Location:43117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134434
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  2. NM_001127442.2NP_001120914.1  carboxypeptidase A5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001120914.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK131191, BC053681, BK000187
    Consensus CDS
    CCDS47713.1
    UniProtKB/Swiss-Prot
    Q8WXQ8
    Related
    ENSP00000393045.2, ENST00000431780.6
    Conserved Domains (2) summary
    pfam02244
    Location:44116
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134380
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  3. NM_001318223.2NP_001305152.1  carboxypeptidase A5 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same isoform (1).
    Source sequence(s)
    AK315256, BC053681, BK000187
    Consensus CDS
    CCDS5819.1
    UniProtKB/Swiss-Prot
    Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2, B2RCS8
    Related
    ENSP00000418183.1, ENST00000461828.5
    Conserved Domains (2) summary
    pfam02244
    Location:43117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134434
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  4. NM_080385.5NP_525124.3  carboxypeptidase A5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_525124.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1). Variants 1, 2, and 4 encode the same isoform.
    Source sequence(s)
    BC053681, BK000187
    Consensus CDS
    CCDS5819.1
    UniProtKB/Swiss-Prot
    Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2
    Related
    ENSP00000417314.1, ENST00000474905.5
    Conserved Domains (2) summary
    pfam02244
    Location:43117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134434
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    130344791..130368730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516704.1XP_011515006.1  carboxypeptidase A5 isoform X2

    See identical proteins and their annotated locations for XP_011515006.1

    UniProtKB/Swiss-Prot
    Q8WXQ8
    Conserved Domains (2) summary
    pfam02244
    Location:44116
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134380
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  2. XM_011516698.1XP_011515000.1  carboxypeptidase A5 isoform X1

    See identical proteins and their annotated locations for XP_011515000.1

    UniProtKB/Swiss-Prot
    Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2
    Related
    ENSP00000420237.1, ENST00000485477.5
    Conserved Domains (2) summary
    pfam02244
    Location:43117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134434
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  3. XM_011516701.1XP_011515003.1  carboxypeptidase A5 isoform X1

    See identical proteins and their annotated locations for XP_011515003.1

    UniProtKB/Swiss-Prot
    Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2
    Conserved Domains (2) summary
    pfam02244
    Location:43117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134434
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  4. XM_011516702.1XP_011515004.1  carboxypeptidase A5 isoform X1

    See identical proteins and their annotated locations for XP_011515004.1

    UniProtKB/Swiss-Prot
    Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2
    Conserved Domains (2) summary
    pfam02244
    Location:43117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134434
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  5. XM_011516703.1XP_011515005.1  carboxypeptidase A5 isoform X1

    See identical proteins and their annotated locations for XP_011515005.1

    UniProtKB/Swiss-Prot
    Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2
    Conserved Domains (2) summary
    pfam02244
    Location:43117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134434
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  6. XM_011516705.1XP_011515007.1  carboxypeptidase A5 isoform X3

    Conserved Domains (2) summary
    pfam02244
    Location:44116
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134279
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  7. XM_005250710.1XP_005250767.1  carboxypeptidase A5 isoform X1

    See identical proteins and their annotated locations for XP_005250767.1

    UniProtKB/Swiss-Prot
    Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2
    Conserved Domains (2) summary
    pfam02244
    Location:43117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134434
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  8. XM_024447000.1XP_024302768.1  carboxypeptidase A5 isoform X1

    Conserved Domains (2) summary
    pfam02244
    Location:43117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134434
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  9. XM_024447001.1XP_024302769.1  carboxypeptidase A5 isoform X1

    Related
    ENSP00000376907.3, ENST00000393213.7
    Conserved Domains (2) summary
    pfam02244
    Location:43117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134434
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  10. XM_005250712.1XP_005250769.1  carboxypeptidase A5 isoform X1

    See identical proteins and their annotated locations for XP_005250769.1

    UniProtKB/Swiss-Prot
    Q8WXQ8
    UniProtKB/TrEMBL
    A4D1M2
    Conserved Domains (2) summary
    pfam02244
    Location:43117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134434
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  11. XM_024446999.1XP_024302767.1  carboxypeptidase A5 isoform X1

    Related
    ENSP00000419025.2, ENST00000466363.6
    Conserved Domains (2) summary
    pfam02244
    Location:43117
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:134434
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
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