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SPINK14 serine peptidase inhibitor Kazal type 14 (putative) [ Homo sapiens (human) ]

Gene ID: 408187, updated on 5-Aug-2022

Summary

Official Symbol
SPINK14provided by HGNC
Official Full Name
serine peptidase inhibitor Kazal type 14 (putative)provided by HGNC
Primary source
HGNC:HGNC:33825
See related
Ensembl:ENSG00000196800 AllianceGenome:HGNC:33825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPINK5L2
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

Location:
5q32
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (148168546..148175619)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (148704264..148709980)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (147548109..147555182)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor Kazal type 5 Neighboring gene uncharacterized LOC124901185 Neighboring gene Sharpr-MPRA regulatory region 6578 Neighboring gene serine peptidase inhibitor Kazal type 6 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease inhibitor Kazal-type 14
Names
Kazal type serine protease inhibitor 5-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001325.2NP_001001325.1  serine protease inhibitor Kazal-type 14 precursor

    See identical proteins and their annotated locations for NP_001001325.1

    Status: VALIDATED

    Source sequence(s)
    JF509943
    Consensus CDS
    CCDS4288.1
    UniProtKB/Swiss-Prot
    M1EY23, Q6IE38
    UniProtKB/TrEMBL
    M1EY23
    Related
    ENSP00000349459.1, ENST00000356972.2
    Conserved Domains (1) summary
    cd01327
    Location:5397
    KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    148168546..148175619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009469.2XP_016864958.1  serine protease inhibitor Kazal-type 14 isoform X1

    UniProtKB/Swiss-Prot
    M1EY23, Q6IE38
    UniProtKB/TrEMBL
    M1EY23
    Conserved Domains (1) summary
    cd01327
    Location:5397
    KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    148704264..148709980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)