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ncor2.S nuclear receptor corepressor 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 407842, updated on 17-Aug-2024

Summary

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Official Symbol
ncor2.S
Official Full Name
nuclear receptor corepressor 2 S homeolog
Primary source
Xenbase:XB-GENE-5963159
Locus tag
XELAEV_18010598mg
See related
EnsemblRapid:ENSXLAG00005009062
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
nx2; smrt; ncor2
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Genomic context

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Location:
chromosome: 1S
Exon count:
50
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (148978265..149208946)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (133230623..133461189)

Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121399491 Neighboring gene uncharacterized LOC108706440 Neighboring gene refilin A L homeolog Neighboring gene uncharacterized LOC121399492

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xenopus embryos lacking specific isoforms of the corepressor SMRT develop abnormal heads. Malartre M, et al. Dev Biol, 2006 Apr 15. PMID 16500640
  2. Alternative splicing generates multiple SMRT transcripts encoding conserved repressor domains linked to variable transcription factor interaction domains. Malartre M, et al. Nucleic Acids Res, 2004. PMID 15342788, Free PMC Article
  3. Recruitment of N-CoR/SMRT-TBLR1 corepressor complex by unliganded thyroid hormone receptor for gene repression during frog development. Tomita A, et al. Mol Cell Biol, 2004 Apr. PMID 15060155, Free PMC Article
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 complexes by unliganded thyroid hormone receptors in transcriptional repression during vertebrate development
    Title: Recruitment of N-CoR/SMRT-TBLR1 corepressor complex by unliganded thyroid hormone receptor for gene repression during frog development.
  2. Embryos lacking specific isoforms of SMRT develop abnormal heads.
    Title: Xenopus embryos lacking specific isoforms of the corepressor SMRT develop abnormal heads.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor corepressor 2 S homeolog
Names
nuclear receptor co-repressor 2
silencing mediator for retinoid and thyroid hormone receptor
silencing mediator of retinoic acid and thyroid hormone receptors

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091023.1 → NP_001084492.1  nuclear receptor corepressor 2 S homeolog

    See identical proteins and their annotated locations for NP_001084492.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ439977
    UniProtKB/TrEMBL
    A0A974DW43, Q1W3Z6
    Conserved Domains (4) summary
    smart00717
    Location:592 → 637
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:592 → 635
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam15784
    Location:140 → 226
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:429 → 472
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    148978265..149208946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018235544.2 → XP_018091033.1  nuclear receptor corepressor 2 S homeolog isoform X5

    UniProtKB/TrEMBL
    A0A8J0TLV2, A0A974DW43

  2. XM_018235570.2 → XP_018091059.1  nuclear receptor corepressor 2 S homeolog isoform X7

    UniProtKB/TrEMBL
    A0A8J0TLX7, A0A974DW43

  3. XM_018235605.2 → XP_018091094.1  nuclear receptor corepressor 2 S homeolog isoform X12

    UniProtKB/TrEMBL
    A0A8J0TX04, A0A974DW43

  4. XM_018235561.2 → XP_018091050.1  nuclear receptor corepressor 2 S homeolog isoform X6

    UniProtKB/TrEMBL
    A0A8J0TUE2, A0A974DW43

  5. XM_018235537.2 → XP_018091026.1  nuclear receptor corepressor 2 S homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J0TVH5, A0A974DW43

  6. XM_018235588.2 → XP_018091077.1  nuclear receptor corepressor 2 S homeolog isoform X9

    UniProtKB/TrEMBL
    A0A8J0TWY6, A0A974DW43

  7. XM_018235552.2 → XP_018091041.1  nuclear receptor corepressor 2 S homeolog isoform X4

    UniProtKB/TrEMBL
    A0A8J0TWV6, A0A974DW43

  8. XM_018235501.2 → XP_018090990.1  nuclear receptor corepressor 2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0TLS0, A0A974DW43
    Conserved Domains (5) summary
    COG5259
    Location:487 → 629
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    TIGR02169
    Location:166 → 456
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam00249
    Location:594 → 637
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:140 → 227
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:430 → 473
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  9. XM_018235597.2 → XP_018091086.1  nuclear receptor corepressor 2 S homeolog isoform X10

    UniProtKB/TrEMBL
    A0A8J0TVM5, A0A974DW43

  10. XM_018235579.2 → XP_018091068.1  nuclear receptor corepressor 2 S homeolog isoform X8

    UniProtKB/TrEMBL
    A0A8J0TUF6, A0A974DW43
    Related
    ENSXLAP00005026529.1, ENSXLAT00005027261.1

  11. XM_041574638.1 → XP_041430572.1  nuclear receptor corepressor 2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0TLS0, A0A974DW43
    Conserved Domains (5) summary
    COG5259
    Location:487 → 629
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    TIGR02169
    Location:166 → 456
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam00249
    Location:594 → 637
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:140 → 227
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:430 → 473
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  12. XM_018235509.2 → XP_018090998.1  nuclear receptor corepressor 2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0TLS0, A0A974DW43
    Related
    ENSXLAP00005026441.1, ENSXLAT00005027173.1
    Conserved Domains (5) summary
    COG5259
    Location:487 → 629
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    TIGR02169
    Location:166 → 456
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam00249
    Location:594 → 637
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:140 → 227
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:430 → 473
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  13. XM_018235529.2 → XP_018091018.1  nuclear receptor corepressor 2 S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J0TLU2, A0A974DW43
    Related
    ENSXLAP00005026481.1, ENSXLAT00005027213.1

  14. XM_041574661.1 → XP_041430595.1  nuclear receptor corepressor 2 S homeolog isoform X11

    UniProtKB/TrEMBL
    A0A8J1LPH2, A0A974DW43
    Related
    ENSXLAP00005026366.1, ENSXLAT00005027097.1
    Conserved Domains (4) summary
    smart00717
    Location:527 → 572
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    COG5259
    Location:420 → 562
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    TIGR02168
    Location:90 → 342
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl21498
    Location:363 → 406
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
Nucleotide Protein Strain
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