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TM4SF1 transmembrane 4 L six family member 1 [ Homo sapiens (human) ]

Gene ID: 4071, updated on 9-Aug-2021


Official Symbol
TM4SF1provided by HGNC
Official Full Name
transmembrane 4 L six family member 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000169908 MIM:191155
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L6; H-L6; M3S1; TAAL6
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]
Broad expression in gall bladder (RPKM 142.0), lung (RPKM 138.0) and 24 other tissues See more
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Genomic context

See TM4SF1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (149369022..149377781, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (149086809..149095436, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane 4 L six family member 18 Neighboring gene ribosomal protein S25 pseudogene 5 Neighboring gene TM4SF1 antisense RNA 1 Neighboring gene uncharacterized LOC105374151 Neighboring gene ribosomal protein L32 pseudogene 8

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of transmembrane 4 L six family member 1 (TM4SF1; L6) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
Component Evidence Code Pubs
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
transmembrane 4 L6 family member 1
membrane component, chromosome 3, surface marker 1
transmembrane 4 superfamily member 1
tumor-associated antigen L6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014220.3NP_055035.1  transmembrane 4 L6 family member 1

    See identical proteins and their annotated locations for NP_055035.1

    Status: REVIEWED

    Source sequence(s)
    AC073522, AC108751, AK130271
    Consensus CDS
    ENSP00000304277.3, ENST00000305366.8
    Conserved Domains (1) summary
    L6_membrane; L6 membrane protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    149369022..149377781 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006385.2XP_016861874.1  transmembrane 4 L6 family member 1 isoform X1

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