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Pss Phosphatidylserine synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40281, updated on 18-Sep-2024

Summary

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Official Symbol
Pssprovided by FlyBase
Official Full Name
Phosphatidylserine synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0287585
Locus tag
Dmel_CG4825
See related
AllianceGenome:FB:FBgn0287585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4825; Dmel\CG4825; l(3)04521; l(3)77CDf; pss; ptdss1
Summary
Enables phosphotransferase activity, for other substituted phosphate groups. Involved in phosphatidylserine biosynthetic process. Located in endomembrane system. Is expressed in adult brain cell body rind; adult fat body; adult gnathal ganglion; and adult head. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
77C6-77C7; 3-47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20522440..20526174, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20515540..20519274, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mitochondrial transcription termination factor 3 Neighboring gene uncharacterized protein Neighboring gene NUBP iron-sulfur cluster assembly factor 2 Neighboring gene Reduction in Cnn dots 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphatidylserine synthase plays an essential role in glia and affects development, as well as the maintenance of neuronal function. Park YJ, et al. iScience, 2021 Aug 20. PMID 34401677, Free PMC Article
  2. Integrative Role of 14-3-3ε in Sleep Regulation. Wei Y, et al. Int J Mol Sci, 2021 Sep 9. PMID 34575915, Free PMC Article
  3. Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms. Yang X, et al. PLoS Genet, 2019 Dec. PMID 31869331, Free PMC Article
  4. ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson's Disease. Valadas JS, et al. Neuron, 2018 Jun 27. PMID 29887339
  5. Adipocyte Metabolic Pathways Regulated by Diet Control the Female Germline Stem Cell Lineage in Drosophila melanogaster. Matsuoka S, et al. Genetics, 2017 Jun. PMID 28396508, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results demonstrate the tissue-autonomous function of CG4825 in regulating cell growth and lipid storage.
    Title: Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-serine-phosphatidylcholine phosphatidyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylserine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylserine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylserine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 

General protein information

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Preferred Names
phosphatidylserine synthase
Names
CDP-diacylglycerol-serine O-phosphatidyltransferase
CG4825-PA
CG4825-PB
Pss-PA
Pss-PB
lethal (3) 77CDf
NP_001262118.1
NP_649242.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20522440..20526174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275189.1 → NP_001262118.1  phosphatidylserine synthase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262118.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PIC3
    Conserved Domains (1) summary
    pfam03034
    Location:150 → 425
    PSS; Phosphatidyl serine synthase

  2. NM_140985.4 → NP_649242.1  phosphatidylserine synthase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649242.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PIC3, Q9VPD3
    Related
    FBpp0077872
    Conserved Domains (1) summary
    pfam03034
    Location:150 → 425
    PSS; Phosphatidyl serine synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPD3.1 Q9VPD3

Gene LinkOut

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