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FSIP2 fibrous sheath interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 401024, updated on 23-Nov-2021

Summary

Official Symbol
FSIP2provided by HGNC
Official Full Name
fibrous sheath interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:21675
See related
Ensembl:ENSG00000188738 MIM:615796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPGF34
Summary
This gene encodes a protein associated with the sperm fibrous sheath. Genes encoding most of the fibrous-sheath associated proteins genes are transcribed only during the postmeiotic period of spermatogenesis. The protein encoded by this gene is specific to spermatogenic cells. Copy number variation in this gene may be associated with testicular germ cell tumors. Pseudogenes associated with this gene are reported on chromosomes 2 and X. [provided by RefSeq, Aug 2016]
Expression
Biased expression in testis (RPKM 4.0), stomach (RPKM 1.4) and 2 other tissues See more
Orthologs
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Genomic context

See FSIP2 in Genome Data Viewer
Location:
2q32.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (185738804..185833290)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (186603531..186698017)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9118 Neighboring gene uncharacterized LOC107985782 Neighboring gene FSIP2 antisense RNA 2 Neighboring gene FSIP2 antisense RNA 1 Neighboring gene fibrous sheath interacting protein 2 pseudogene Neighboring gene uncharacterized LOC107985783 Neighboring gene ribosomal protein L21 pseudogene 32

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34780, FLJ44048, FLJ44063, FLJ44101, FLJ44116, DKFZp781I24108

General protein information

Preferred Names
fibrous sheath-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051365.1 RefSeqGene

    Range
    4910..99396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173651.4NP_775922.3  fibrous sheath-interacting protein 2

    Status: REVIEWED

    Source sequence(s)
    AC007966, AC008174
    Consensus CDS
    CCDS54426.2
    UniProtKB/Swiss-Prot
    Q5CZC0
    Related
    ENSP00000401306.1, ENST00000424728.6
    Conserved Domains (2) summary
    pfam05672
    Location:213307
    MAP7; MAP7 (E-MAP-115) family
    pfam15783
    Location:59016774
    FSIP2; Fibrous sheath-interacting protein 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    185738804..185833290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452886.1XP_024308654.1  fibrous sheath-interacting protein 2 isoform X1

    Conserved Domains (2) summary
    cl25742
    Location:212305
    ERM; Ezrin/radixin/moesin family
    cl26511
    Location:189408
    Neuromodulin_N; Gap junction protein N-terminal region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207482.2: Suppressed sequence

    Description
    NM_207482.2: This RefSeq was permanently suppressed because the CDS was partial.
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