Fsip2 fibrous sheath-interacting protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fsip2provided by MGI
Official Full Name: fibrous sheath-interacting protein 2provided by MGI
Primary source: MGI:MGI:2664111
See related: Ensembl:ENSMUSG00000075249 AllianceGenome:MGI:2664111
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to act upstream of or within with a positive effect on protein localization to cilium and sperm axoneme assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in spermatogenic failure 34. Orthologous to human FSIP2 (fibrous sheath interacting protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Restricted expression toward testis adult (RPKM 3.1) See more
Orthologs: all
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Genomic context

Location:: 2 D; 2 49.08 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (82773978..82839281)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (82943634..83008937)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypomorphic and hypermorphic mouse models of Fsip2 indicate its dosage-dependent roles in sperm tail and acrosome formation.
Title: Hypomorphic and hypermorphic mouse models of Fsip2 indicate its dosage-dependent roles in sperm tail and acrosome formation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within_positive_effect flagellated sperm motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cilium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect sperm axoneme assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in motile cilium	IC Inferred by Curator more info	PubMed
located_in sperm end piece	IEA Inferred from Electronic Annotation more info
located_in sperm end piece	ISO Inferred from Sequence Orthology more info
located_in sperm head-tail coupling apparatus	IEA Inferred from Electronic Annotation more info
located_in sperm head-tail coupling apparatus	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	IEA Inferred from Electronic Annotation more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in sperm principal piece	IEA Inferred from Electronic Annotation more info
located_in sperm principal piece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibrous sheath-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370266.1 → NP_001357195.1 fibrous sheath-interacting protein 2

Status: VALIDATED

Source sequence(s)

AL845500

UniProtKB/Swiss-Prot

A2ARZ1, A2ARZ3

Related

ENSMUSP00000120314.3, ENSMUST00000143764.9

Conserved Domains (4) summary

pfam15783
Location:5996 → 6860

FSIP2; Fibrous sheath-interacting protein 2

pfam16001
Location:5622 → 6041

DUF4775; Domain of unknown function (DUF4775)

pfam03154
Location:5503 → 5649

Atrophin-1; Atrophin-1 family

pfam17380
Location:136 → 309

DUF5401; Family of unknown function (DUF5401)