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EEIG1 estrogen-induced osteoclastogenesis regulator 1 [ Homo sapiens (human) ]

Gene ID: 399665, updated on 3-Dec-2023

Summary

Official Symbol
EEIG1provided by HGNC
Official Full Name
estrogen-induced osteoclastogenesis regulator 1provided by HGNC
Primary source
HGNC:HGNC:31419
See related
Ensembl:ENSG00000167106 MIM:610891; AllianceGenome:HGNC:31419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYM-3A; FAM102A; C9orf132; bA203J24.7
Expression
Ubiquitous expression in stomach (RPKM 55.4), small intestine (RPKM 33.1) and 25 other tissues See more
Orthologs
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Genomic context

See EEIG1 in Genome Data Viewer
Location:
9q34.11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (127940582..127980989, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140148362..140188761, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130702861..130743268, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:130685680-130686879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130688781-130689504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130689505-130690228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130690229-130690952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130691676-130692399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130693123-130693846 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130696662-130697162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130697163-130697663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29062 Neighboring gene uncharacterized LOC124902280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130704889-130705418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130708322-130708822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130708823-130709323 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130717798-130718764 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130723095-130723703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130723748-130724584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130724585-130725420 Neighboring gene Sharpr-MPRA regulatory region 6856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130730939-130731467 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130735756-130736498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130736499-130737242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29063 Neighboring gene conserved acetylation island sequence 15 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130763335-130763870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130763871-130764404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29067 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29068 Neighboring gene Sharpr-MPRA regulatory region 5179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130817345-130818242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20323 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:130835790-130836290 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:130836291-130836791 Neighboring gene solute carrier family 25 member 25 Neighboring gene nuclear apoptosis inducing factor 1 Neighboring gene Sharpr-MPRA regulatory region 4771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130853709-130854229 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:130854230-130854750 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130859824-130860560 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130860561-130861298

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC50853

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
early estrogen-induced gene 1 protein
Names
family with sequence similarity 102 member A
protein FAM102A
sym-3 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035254.3NP_001030331.1  early estrogen-induced gene 1 protein isoform a

    See identical proteins and their annotated locations for NP_001030331.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK058004, AL157935, BC047949, BI008660, CN482844
    Consensus CDS
    CCDS35150.1
    UniProtKB/Swiss-Prot
    A2A329, Q5T9C2, Q8TEL4
    Related
    ENSP00000362187.1, ENST00000373095.6
    Conserved Domains (1) summary
    pfam10358
    Location:12152
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
  2. NM_203305.3NP_976050.1  early estrogen-induced gene 1 protein isoform b

    See identical proteins and their annotated locations for NP_976050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AL157935, BC047949, BI008660
    Consensus CDS
    CCDS6888.1
    UniProtKB/Swiss-Prot
    Q5T9C2
    Related
    ENSP00000362176.4, ENST00000373084.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    127940582..127980989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    140148362..140188761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)