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LIPC lipase C, hepatic type [ Homo sapiens (human) ]

Gene ID: 3990, updated on 5-Jan-2022

Summary

Official Symbol
LIPCprovided by HGNC
Official Full Name
lipase C, hepatic typeprovided by HGNC
Primary source
HGNC:HGNC:6619
See related
Ensembl:ENSG00000166035 MIM:151670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HL; HTGL; LIPH; HDLCQ12
Summary
LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 24.9) and kidney (RPKM 1.5) See more
Orthologs
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Genomic context

See LIPC in Genome Data Viewer
Location:
15q21.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (58410457..58569844)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (58724190..58862043)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5540 Neighboring gene Sharpr-MPRA regulatory region 459 Neighboring gene Sharpr-MPRA regulatory region 12189 Neighboring gene LIPC antisense RNA 1 Neighboring gene ADAM metallopeptidase domain 10 Neighboring gene G protein subunit gamma 10 pseudogene Neighboring gene high mobility group box 1 pseudogene 51

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Hepatic lipase deficiency
MedGen: C3151466 OMIM: 614025 GeneReviews: Not available
Compare labs
High density lipoprotein cholesterol level quantitative trait locus 12
MedGen: C2675071 OMIM: 612797 GeneReviews: Not available
Compare labs
Type 2 diabetes mellitus
MedGen: C0011860 OMIM: 125853 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
EBI GWAS Catalog
A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
EBI GWAS Catalog
A genome-wide assessment of variability in human serum metabolism.
EBI GWAS Catalog
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Common genetic variation and performance on standardized cognitive tests.
EBI GWAS Catalog
Common variants at 30 loci contribute to polygenic dyslipidemia.
EBI GWAS Catalog
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
EBI GWAS Catalog
Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.
EBI GWAS Catalog
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
EBI GWAS Catalog
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
EBI GWAS Catalog
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
EBI GWAS Catalog
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
EBI GWAS Catalog
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
EBI GWAS Catalog
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
EBI GWAS Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
EBI GWAS Catalog
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
EBI GWAS Catalog
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
EBI GWAS Catalog
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
EBI GWAS Catalog
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
EBI GWAS Catalog
Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
EBI GWAS Catalog
Seven new loci associated with age-related macular degeneration.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables apolipoprotein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables apolipoprotein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipoprotein lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables low-density lipoprotein particle binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase activity TAS
Traceable Author Statement
more info
PubMed 
enables triglyceride lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in chylomicron remnant clearance TAS
Traceable Author Statement
more info
PubMed 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in high-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intermediate-density lipoprotein particle remodeling TAS
Traceable Author Statement
more info
PubMed 
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in low-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylcholine catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in reverse cholesterol transport IC
Inferred by Curator
more info
PubMed 
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in triglyceride catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in very-low-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hepatic triacylglycerol lipase
Names
Triacylglycerol lipase
hepatic lipase
lipase member C
lipase, hepatic
lysophospholipase
phospholipase A1
NP_000227.2
XP_005254429.1
XP_005254431.2
XP_006720565.1
XP_016877665.1
XP_024305684.1
XP_024305685.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011465.2 RefSeqGene

    Range
    5016..142869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000236.3NP_000227.2  hepatic triacylglycerol lipase precursor

    See identical proteins and their annotated locations for NP_000227.2

    Status: REVIEWED

    Source sequence(s)
    AC018904, AI823349, AK315306, AV645541, BC146659, D83548
    Consensus CDS
    CCDS10166.1
    UniProtKB/Swiss-Prot
    P11150
    UniProtKB/TrEMBL
    A6H8L5
    Related
    ENSP00000299022.5, ENST00000299022.10
    Conserved Domains (2) summary
    cd01758
    Location:352487
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:24349
    Lipase; Lipase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    58410457..58569844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449916.1XP_024305684.1  hepatic triacylglycerol lipase isoform X2

    Related
    ENSP00000348425.6, ENST00000356113.10
    Conserved Domains (2) summary
    cd01758
    Location:352487
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:24349
    Lipase; Lipase
  2. XM_005254372.1XP_005254429.1  hepatic triacylglycerol lipase isoform X2

    See identical proteins and their annotated locations for XP_005254429.1

    UniProtKB/Swiss-Prot
    P11150
    Related
    ENSP00000395002.2, ENST00000433326.2
    Conserved Domains (2) summary
    cd01758
    Location:352487
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:24349
    Lipase; Lipase
  3. XM_024449917.1XP_024305685.1  hepatic triacylglycerol lipase isoform X2

    Conserved Domains (2) summary
    cd01758
    Location:352487
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:24349
    Lipase; Lipase
  4. XM_006720502.4XP_006720565.1  hepatic triacylglycerol lipase isoform X3

    Conserved Domains (3) summary
    TIGR03230
    Location:15450
    lipo_lipase; lipoprotein lipase
    cd00707
    Location:2298
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:305440
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
  5. XM_017022176.1XP_016877665.1  hepatic triacylglycerol lipase isoform X4

  6. XM_005254374.4XP_005254431.2  hepatic triacylglycerol lipase isoform X1

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