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ESR1 estrogen receptor 1 [ Sus scrofa (pig) ]

Gene ID: 397435, updated on 17-Aug-2024

Summary

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Official Symbol
ESR1provided by VGNC
Official Full Name
estrogen receptor 1provided by VGNC
Primary source
VGNC:VGNC:103089
See related
Ensembl:ENSSSCG00000025777
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
ER-alpha
Expression
Biased expression in ovary (RPKM 6.5) and liver (RPKM 0.4) See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (14217032..14604906, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (16546666..16577163, complement)

Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene MYC target 1 Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene uncharacterized LOC102163894 Neighboring gene coiled-coil domain containing 170 Neighboring gene acidic residue methyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Allelic variability of estrogen receptor (ESR) gene and its effect on litter traits of Doom pigs. Rahman M, et al. Trop Anim Health Prod, 2021 May 12. PMID 33977374
  2. Assignment of the ligand binding site of the porcine estradiol receptor to the N-terminal 17 kDa part of domain E. Thole HH. FEBS Lett, 1993 Apr 5. PMID 8458437
  3. The C-terminal half of the porcine estradiol receptor contains no post-translational modification: determination of the primary structure. Bökenkamp D, et al. Mol Cell Endocrinol, 1994 Sep. PMID 7988744
  4. Surface mapping of the ligand-filled C-terminal half of the porcine estradiol receptor by restricted proteolysis. Thole HH, et al. Eur J Biochem, 1995 Jul 15. PMID 7635163
  5. Expression of oestrogen receptor α and oestrogen receptor β in the uterus of the pregnant swine. Knapczyk-Stwora K, et al. Reprod Domest Anim, 2011 Feb. PMID 19645857

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Evaluation of reproductive traits and ovarian and uterine morphology of sows with different genotypes for the estrogen receptor, prolactin receptor, and follicle-stimulating hormone subunit beta genes.
    Title: Evaluation of reproductive traits and ovarian and uterine morphology of sows with different genotypes for the estrogen receptor, prolactin receptor, and follicle-stimulating hormone subunit beta genes.
  2. Allelic variability of estrogen receptor (ESR) gene and its effect on litter traits of Doom pigs.
    Title: Allelic variability of estrogen receptor (ESR) gene and its effect on litter traits of Doom pigs.
  3. ESR(B), FSHbeta(B), CTNNAL1(G), miR-27a(A) allele was favorable for litter size traits. Furthermore, combined genetic effect analysis showed ESR(AA)FSHbeta(BB), ESR(AA)CTNNAL1(CG), ESR(AA)miR-27a(AA), FSHbeta(BB)CTNNAL1(CC), FSHbeta(BB)miR-27a(AA) and CTNNAL1(CG) miR-27a(AB) was the favorable combined genotype for litter size traits.
    Title: Genetic effect and combined genotype effect of ESR, FSHβ, CTNNAL1 and miR-27a loci on litter size in a Large White population.
  4. These results will improve the understanding of the functions of the ESR1 in spermatogenesis within the reproductive tract and will shed light on ESR1 as a candidate in the selection of boar with good sperm quality and fertility.
    Title: Association study and expression analysis of porcine ESR1 as a candidate gene for boar fertility and sperm quality.
  5. study is the first one to demonstrate the presence of estrogen receptors alpha and beta in the porcine uterus not only at the beginning but also at mid- and late pregnancy
    Title: Expression of oestrogen receptor α and oestrogen receptor β in the uterus of the pregnant swine.
  6. findings suggest that testicular estrogen receptors alpha and beta may be important factors contributing to onset and maintenance of spermatogenesis in the boar.
    Title: Expression of oestrogen receptors alpha and beta and of aromatase in the testis of immature and mature boars.
  7. Results showed that the effects of FSHb, ESR, and PRLR genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
    Title: [Effects of multi-genes for reproductive traits in Tibet pig].
  8. The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.
    Title: Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line.
  9. The expression of mRNAs for ERalpha, ERbeta and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
    Title: Messenger RNA levels of estrogen receptors alpha and beta and progesterone receptors in the cyclic and inseminated/early pregnant sow uterus.
  10. positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
    Title: Evidence for estrogen receptor alpha and beta expression in skeletal muscle of pigs.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear estrogen receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
estrogen receptor
Names
ER
estradiol receptor
estrogen receptor alpha
nuclear receptor subfamily 3 group A member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214220.1 → NP_999385.1  estrogen receptor

    See identical proteins and their annotated locations for NP_999385.1

    Status: PROVISIONAL

    Source sequence(s)
    Z37167
    UniProtKB/Swiss-Prot
    Q29040
    UniProtKB/TrEMBL
    A2TEV4
    Conserved Domains (4) summary
    cd06949
    Location:310 → 547
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 261
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:556 → 595
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

    Range
    14217032..14604906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021083057.1 → XP_020938716.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A2TEV4
    Related
    ENSSSCP00000039928.2, ENSSSCT00000063430.2
    Conserved Domains (4) summary
    cd06949
    Location:312 → 549
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 263
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:558 → 597
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  2. XM_021083070.1 → XP_020938729.1  estrogen receptor isoform X2

    UniProtKB/Swiss-Prot
    Q29040
    UniProtKB/TrEMBL
    A2TEV4
    Related
    ENSSSCP00000030835.2, ENSSSCT00000035147.2
    Conserved Domains (4) summary
    cd06949
    Location:310 → 547
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 261
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:556 → 595
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  3. XM_021083050.1 → XP_020938709.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A2TEV4
    Conserved Domains (4) summary
    cd06949
    Location:312 → 549
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 263
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:558 → 597
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  4. XM_021083034.1 → XP_020938693.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A2TEV4
    Conserved Domains (4) summary
    cd06949
    Location:312 → 549
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 263
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:558 → 597
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  5. XM_021083018.1 → XP_020938677.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A2TEV4
    Conserved Domains (4) summary
    cd06949
    Location:312 → 549
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 263
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:558 → 597
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  6. XM_021083026.1 → XP_020938685.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A2TEV4
    Conserved Domains (4) summary
    cd06949
    Location:312 → 549
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 263
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:558 → 597
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  7. XM_021083012.1 → XP_020938671.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A2TEV4
    Conserved Domains (4) summary
    cd06949
    Location:312 → 549
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 263
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:558 → 597
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  8. XM_021083002.1 → XP_020938661.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A2TEV4
    Conserved Domains (4) summary
    cd06949
    Location:312 → 549
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 263
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:558 → 597
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  9. XM_021083061.1 → XP_020938720.1  estrogen receptor isoform X2

    UniProtKB/Swiss-Prot
    Q29040
    UniProtKB/TrEMBL
    A2TEV4
    Related
    ENSSSCP00000026750.3, ENSSSCT00000024477.3
    Conserved Domains (4) summary
    cd06949
    Location:310 → 547
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 261
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:556 → 595
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  10. XM_021083031.1 → XP_020938690.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A2TEV4
    Conserved Domains (4) summary
    cd06949
    Location:312 → 549
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 263
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:558 → 597
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  11. XM_021083075.1 → XP_020938734.1  estrogen receptor isoform X2

    UniProtKB/Swiss-Prot
    Q29040
    UniProtKB/TrEMBL
    A2TEV4
    Conserved Domains (4) summary
    cd06949
    Location:310 → 547
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 261
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:556 → 595
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  12. XM_021083009.1 → XP_020938668.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A2TEV4
    Conserved Domains (4) summary
    cd06949
    Location:312 → 549
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 263
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:558 → 597
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  13. XM_021083041.1 → XP_020938700.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A2TEV4
    Conserved Domains (4) summary
    cd06949
    Location:312 → 549
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 263
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:558 → 597
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

  14. XM_021083045.1 → XP_020938704.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A2TEV4
    Conserved Domains (4) summary
    cd06949
    Location:312 → 549
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:180 → 263
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 181
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:558 → 597
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q29040.1 GenPept UniProtKB/Swiss-Prot:Q29040

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