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Esr1 estrogen receptor 1 (alpha) [ Mus musculus (house mouse) ]

Gene ID: 13982, updated on 11-Jun-2024

Summary

Official Symbol
Esr1provided by MGI
Official Full Name
estrogen receptor 1 (alpha)provided by MGI
Primary source
MGI:MGI:1352467
See related
Ensembl:ENSMUSG00000019768 AllianceGenome:MGI:1352467
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ER; ERa; ESR; Estr; Estra; Nr3a1; ERalpha; ER-alpha
Summary
This gene encodes an estrogen receptor, a member of the nuclear hormone family of intracellular receptors. The encoded protein, activated by the sex hormone estrogen, is a transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Similar genes in human have been implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Biased expression in ovary adult (RPKM 13.9), subcutaneous fat pad adult (RPKM 12.1) and 7 other tissues See more
Orthologs
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Genomic context

See Esr1 in Genome Data Viewer
Location:
10 A1; 10 2.03 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4561989..4955633)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (4611989..5005633)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25624 Neighboring gene coiled-coil domain containing 170 Neighboring gene predicted gene, 22739 Neighboring gene STARR-seq mESC enhancer starr_25622 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5733988-5734171 Neighboring gene STARR-seq mESC enhancer starr_25621 Neighboring gene glutathione S-transferase, pi 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25620 Neighboring gene STARR-seq mESC enhancer starr_25619 Neighboring gene STARR-seq mESC enhancer starr_25618 Neighboring gene STARR-seq mESC enhancer starr_25616 Neighboring gene STARR-seq mESC enhancer starr_25614 Neighboring gene STARR-seq mESC enhancer starr_25613 Neighboring gene STARR-seq mESC enhancer starr_25612 Neighboring gene spectrin repeat containing, nuclear envelope 1 Neighboring gene STARR-positive B cell enhancer ABC_E2314 Neighboring gene STARR-seq mESC enhancer starr_25609 Neighboring gene STARR-seq mESC enhancer starr_25607 Neighboring gene predicted gene, 51757 Neighboring gene predicted gene, 23573

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled estrogen receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables TFIIB-class transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables estrogen response element binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear estrogen receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear steroid receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol 3-kinase regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type 1 metabotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in Sertoli cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within androgen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within antral ovarian follicle growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to estrogen stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to estrogen stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular estrogen receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular steroid hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland branching involved in pregnancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitotic nuclear division NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within prostate epithelial cord elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to estradiol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in steroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within uterus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within vagina development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
estrogen receptor
Names
C-terminally-truncated estrogen receptor alpha product-4
C-terminally-truncated estrogen receptor alpha product-5
C-terminally-truncated estrogen receptor alpha product-6
C-terminally-truncated estrogen receptor alpha product-7
estradiol receptor
nuclear receptor subfamily 3 group A member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302531.2NP_001289460.1  estrogen receptor isoform 1

    See identical proteins and their annotated locations for NP_001289460.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 6 all encode the same isoform (1).
    Source sequence(s)
    AC153573, AC156393
    Consensus CDS
    CCDS56678.1
    UniProtKB/Swiss-Prot
    P19785, Q9JJT5, Q9QY51, Q9QY52
    UniProtKB/TrEMBL
    B3VQI7, E7FJU2
    Related
    ENSMUSP00000101214.2, ENSMUST00000105589.2
    Conserved Domains (4) summary
    cd06949
    Location:314551
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:184265
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42185
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:556599
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  2. NM_001302532.2NP_001289461.1  estrogen receptor isoform 1

    See identical proteins and their annotated locations for NP_001289461.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 6 all encode the same isoform (1).
    Source sequence(s)
    AC153573, AC156393, AC158617
    Consensus CDS
    CCDS56678.1
    UniProtKB/Swiss-Prot
    P19785, Q9JJT5, Q9QY51, Q9QY52
    UniProtKB/TrEMBL
    B3VQI7, E7FJU2
    Related
    ENSMUSP00000101215.2, ENSMUST00000105590.8
    Conserved Domains (4) summary
    cd06949
    Location:314551
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:184265
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42185
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:556599
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  3. NM_001302533.2NP_001289462.1  estrogen receptor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon in the 3' coding region and uses an upstream alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC153573, AC156393
    UniProtKB/TrEMBL
    D3Z6V3
    Related
    ENSMUSP00000101213.2, ENSMUST00000105588.8
    Conserved Domains (3) summary
    cd07171
    Location:184265
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42185
    Oest_recep; Oestrogen receptor
    cl11397
    Location:314416
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  4. NM_001428459.1NP_001415388.1  estrogen receptor isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC153573, AC156393, AC158617
    UniProtKB/Swiss-Prot
    P19785, Q9JJT5, Q9QY51, Q9QY52
    UniProtKB/TrEMBL
    B3VQI7, E7FJU2
  5. NM_007956.6NP_031982.1  estrogen receptor isoform 1

    See identical proteins and their annotated locations for NP_031982.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, 3, and 6 all encode the same isoform (1).
    Source sequence(s)
    AC153573, AC156393, AC158617
    Consensus CDS
    CCDS56678.1
    UniProtKB/Swiss-Prot
    P19785, Q9JJT5, Q9QY51, Q9QY52
    UniProtKB/TrEMBL
    B3VQI7, E7FJU2
    Related
    ENSMUSP00000070070.8, ENSMUST00000067086.14
    Conserved Domains (4) summary
    cd06949
    Location:314551
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:184265
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42185
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:556599
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

RNA

  1. NR_126357.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' region, contains an alternate internal exon and uses an upstream alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC153573, AC158617, AC158639
    Related
    ENSMUST00000149195.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    4561989..4955633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243066.4XP_011241368.1  estrogen receptor isoform X1

    See identical proteins and their annotated locations for XP_011241368.1

    UniProtKB/Swiss-Prot
    P19785, Q9JJT5, Q9QY51, Q9QY52
    UniProtKB/TrEMBL
    B3VQI7, E7FJU2
    Conserved Domains (4) summary
    cd06949
    Location:314551
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:184265
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42185
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:556599
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  2. XM_011243068.4XP_011241370.1  estrogen receptor isoform X1

    See identical proteins and their annotated locations for XP_011241370.1

    UniProtKB/Swiss-Prot
    P19785, Q9JJT5, Q9QY51, Q9QY52
    UniProtKB/TrEMBL
    B3VQI7, E7FJU2
    Conserved Domains (4) summary
    cd06949
    Location:314551
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:184265
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42185
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:556599
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  3. XM_006512435.3XP_006512498.1  estrogen receptor isoform X1

    See identical proteins and their annotated locations for XP_006512498.1

    UniProtKB/Swiss-Prot
    P19785, Q9JJT5, Q9QY51, Q9QY52
    UniProtKB/TrEMBL
    B3VQI7, E7FJU2
    Conserved Domains (4) summary
    cd06949
    Location:314551
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:184265
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42185
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:556599
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  4. XM_006512434.5XP_006512497.1  estrogen receptor isoform X1

    See identical proteins and their annotated locations for XP_006512497.1

    UniProtKB/Swiss-Prot
    P19785, Q9JJT5, Q9QY51, Q9QY52
    UniProtKB/TrEMBL
    B3VQI7, E7FJU2
    Conserved Domains (4) summary
    cd06949
    Location:314551
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:184265
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42185
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:556599
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  5. XM_036155590.1XP_036011483.1  estrogen receptor isoform X2

    UniProtKB/TrEMBL
    A0A1W7GYW9, A0A1W7GYY4
    Conserved Domains (3) summary
    cd07171
    Location:184265
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42185
    Oest_recep; Oestrogen receptor
    cl11397
    Location:314370
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  6. XM_006512433.5XP_006512496.1  estrogen receptor isoform X1

    See identical proteins and their annotated locations for XP_006512496.1

    UniProtKB/Swiss-Prot
    P19785, Q9JJT5, Q9QY51, Q9QY52
    UniProtKB/TrEMBL
    B3VQI7, E7FJU2
    Conserved Domains (4) summary
    cd06949
    Location:314551
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:184265
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42185
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:556599
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal