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LGALS8 galectin 8 [ Homo sapiens (human) ]

Gene ID: 3964, updated on 6-Jan-2019

Summary

Official Symbol
LGALS8provided by HGNC
Official Full Name
galectin 8provided by HGNC
Primary source
HGNC:HGNC:6569
See related
Ensembl:ENSG00000116977 MIM:606099
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gal-8; PCTA1; PCTA-1; Po66-CBP
Summary
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 17.5), skin (RPKM 16.3) and 25 other tissues See more
Orthologs

Genomic context

See LGALS8 in Genome Data Viewer
Location:
1q43
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (236518214..236552981)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (236681514..236716281)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase 3 pseudogene Neighboring gene EDAR associated death domain Neighboring gene enolase 1 pseudogene 1 Neighboring gene uncharacterized LOC107985367 Neighboring gene LGALS8 antisense RNA 1 Neighboring gene HEAT repeat containing 1 Neighboring gene control region 3 heart enhancer Neighboring gene VISTA enhancer hs2135 Neighboring gene actinin alpha 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of LGALS8 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphatic endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
xenophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
galectin-8
Names
Po66 carbohydrate binding protein
galectin-8g
lectin, galactoside-binding, soluble, 8
po66 carbohydrate-binding protein
prostate carcinoma tumor antigen 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006499.4NP_006490.3  galectin-8 isoform a

    See identical proteins and their annotated locations for NP_006490.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 4 encode the longer isoform (a).
    Source sequence(s)
    AK098613, AL359921, BC016486, DB053616
    Consensus CDS
    CCDS1611.1
    UniProtKB/Swiss-Prot
    O00214
    Related
    ENSP00000408657.2, ENST00000450372.6
    Conserved Domains (2) summary
    smart00908
    Location:236356
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:18151
    Gal-bind_lectin; Galactoside-binding lectin
  2. NM_201543.2NP_963837.1  galectin-8 isoform b

    See identical proteins and their annotated locations for NP_963837.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. Variants 2 and 3 encode a shorter isoform (b) that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AL359921, BC016486, DB053616
    Consensus CDS
    CCDS1612.1
    UniProtKB/Swiss-Prot
    O00214
    Related
    ENSP00000342139.6, ENST00000341872.10
    Conserved Domains (2) summary
    smart00908
    Location:194314
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:18151
    Gal-bind_lectin; Galactoside-binding lectin
  3. NM_201544.2NP_963838.1  galectin-8 isoform b

    See identical proteins and their annotated locations for NP_963838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. Variants 2 and 3 encode a shorter isoform (b) that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AL359921, BC016486, BP280070
    Consensus CDS
    CCDS1612.1
    UniProtKB/Swiss-Prot
    O00214
    Related
    ENSP00000355543.4, ENST00000366584.8
    Conserved Domains (2) summary
    smart00908
    Location:194314
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:18151
    Gal-bind_lectin; Galactoside-binding lectin
  4. NM_201545.2NP_963839.1  galectin-8 isoform a

    See identical proteins and their annotated locations for NP_963839.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4 encode a longer isoform (a).
    Source sequence(s)
    AK098613, AL359921, BC016486, BP371701
    Consensus CDS
    CCDS1611.1
    UniProtKB/Swiss-Prot
    O00214
    Related
    ENSP00000309576.2, ENST00000352231.6
    Conserved Domains (2) summary
    smart00908
    Location:236356
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:18151
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    236518214..236552981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544188.3XP_011542490.1  galectin-8 isoform X1

    Conserved Domains (2) summary
    smart00908
    Location:236310
    Gal-bind_lectin; Galactoside-binding lectin
    pfam00337
    Location:18151
    Gal-bind_lectin; Galactoside-binding lectin
  2. XM_017001274.2XP_016856763.1  galectin-8 isoform X2

  3. XM_017001275.2XP_016856764.1  galectin-8 isoform X3

    Related
    ENSP00000385999.3, ENST00000406509.7
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