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LGALS3BP galectin 3 binding protein [ Homo sapiens (human) ]

Gene ID: 3959, updated on 10-Dec-2024

Summary

Official Symbol
LGALS3BPprovided by HGNC
Official Full Name
galectin 3 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:6564
See related
Ensembl:ENSG00000108679 MIM:600626; AllianceGenome:HGNC:6564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B
Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in stomach (RPKM 179.8), colon (RPKM 156.8) and 25 other tissues See more
Orthologs
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Genomic context

See LGALS3BP in Genome Data Viewer
Location:
17q25.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78971255..78979923, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79866027..79877550, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76967337..76976005, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904068 Neighboring gene Sharpr-MPRA regulatory region 3779 Neighboring gene MPRA-validated peak3021 silencer Neighboring gene TIMP metallopeptidase inhibitor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76869765-76870265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76874955-76875848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76875849-76876740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76877535-76878035 Neighboring gene Sharpr-MPRA regulatory region 5911/8204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9076 Neighboring gene CEP295 N-terminal like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76898462-76899062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76911943-76912638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76912639-76913334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76914785-76915760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12914 Neighboring gene Sharpr-MPRA regulatory region 14803 Neighboring gene Sharpr-MPRA regulatory region 6708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76972258-76972941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76976039-76977031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12915 Neighboring gene calcium activated nucleotidase 1 Neighboring gene C1QTNF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9078 Neighboring gene C1q and TNF related 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 replication is inhibited by LGALS3BP (M2BP) overexpression in 293HEK cells PubMed
Knockdown of 90K/LGALS3BP by siRNA enhances replication and infectivity of HIV-1 in TZM-bl cells and primary macrophages PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The two central protein-binding domains (residues 127-409) of 90K/LGALS3BP are required for inhibition of gp160 processing and incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
env The expression of 90K/LGALS3BP downregulates the relative amounts of mature gp120/gp41, whereas it upregulates the relative levels of uncleaved gp160 precursor inhibiting incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
Envelope surface glycoprotein gp160, precursor env The expression of 90K/LGALS3BP downregulates the relative amounts of mature gp120/gp41, whereas it upregulates the relative levels of uncleaved gp160 precursor inhibiting incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
env The two central protein-binding domains (residues 127-409) of 90K/LGALS3BP are required for inhibition of gp160 processing and incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
Envelope transmembrane glycoprotein gp41 env The two central protein-binding domains (residues 127-409) of 90K/LGALS3BP are required for inhibition of gp160 processing and incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
env The expression of 90K/LGALS3BP downregulates the relative amounts of mature gp120/gp41, whereas it upregulates the relative levels of uncleaved gp160 precursor inhibiting incorporation of the viral gp120/gp41 glycoproteins into progeny virions PubMed
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with lectin, galactoside-binding, soluble, 3 binding protein (LGALS3BP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag HIV-1 Gag trafficking to the plasma membrane is inhibited by LGALS3BP (M2BP) and the inhibition by LGALS3BP is dependent upon vimentin PubMed
gag HIV-1 Gag binds to LGALS3BP (M2BP) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

General protein information

Preferred Names
galectin-3-binding protein
Names
L3 antigen
MAC2BP
Mac-2-binding protein
basement membrane autoantigen p105
lectin galactoside-binding soluble 3-binding protein
mac-2 BP
serum protein 90K
transport and golgi organization 10 homolog B
tumor-associated antigen 90K
NP_005558.1
XP_054172018.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005567.4NP_005558.1  galectin-3-binding protein precursor

    See identical proteins and their annotated locations for NP_005558.1

    Status: REVIEWED

    Source sequence(s)
    BC002403, L13210
    Consensus CDS
    CCDS11759.1
    UniProtKB/Swiss-Prot
    A0A0S2Z3Y1, Q08380, Q7M4S0, Q9UCH8, Q9UCH9, Q9UCI0
    UniProtKB/TrEMBL
    B4DVE1
    Related
    ENSP00000262776.2, ENST00000262776.8
    Conserved Domains (3) summary
    smart00202
    Location:24124
    SR; Scavenger receptor Cys-rich
    cd18304
    Location:136247
    BTB_POZ_M2BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP)
    cd18496
    Location:256329
    BACK_LGALS3BP; BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding protein (LGALS3BP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    78971255..78979923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    79866027..79877550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316043.1XP_054172018.1  galectin-3-binding protein isoform X1

    UniProtKB/Swiss-Prot
    A0A0S2Z3Y1, Q08380, Q7M4S0, Q9UCH8, Q9UCH9, Q9UCI0
    UniProtKB/TrEMBL
    B4DVE1