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LGALS1 galectin 1 [ Homo sapiens (human) ]

Gene ID: 3956, updated on 6-Jan-2019

Summary

Official Symbol
LGALS1provided by HGNC
Official Full Name
galectin 1provided by HGNC
Primary source
HGNC:HGNC:6561
See related
Ensembl:ENSG00000100097 MIM:150570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBP; GAL1
Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 642.6), endometrium (RPKM 479.1) and 23 other tissues See more
Orthologs

Genomic context

See LGALS1 in Genome Data Viewer
Location:
22q13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (37675606..37679802)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38071613..38075809)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene pyridoxal phosphatase Neighboring gene RNA, 7SL, cytoplasmic 385, pseudogene Neighboring gene nucleolar protein 12 Neighboring gene TRIO and F-actin binding protein Neighboring gene uncharacterized LOC102724378

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Galectin 1 binds to HIV-1 gp120 by recognizing clustered CX glycan patches of gp120 in a beta-galactoside-dependent manner. CD4 plays a role as a ligand for the binding between Galectin 1 and gp120 PubMed
env Galectin-1, a dimeric beta-galactoside-binding protein, promotes infection with CCR5-tropic, CXCR4-tropic, and CCR5/CXCR4 dual-tropic HIV-1 variants by facilitating attachment of HIV-1 gp120 to CD4 at the cell surface PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686E23103

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
lactose binding IEA
Inferred from Electronic Annotation
more info
 
laminin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell costimulation IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
plasma cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
NOT positive regulation of dendritic cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of erythrocyte aggregation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
response to axon injury IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to isolation stress IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
galectin-1
Names
14 kDa laminin-binding protein
14 kDa lectin
HBL
HLBP14
HPL
S-Lac lectin 1
beta-galactoside-binding lectin L-14-I
beta-galactoside-binding protein 14kDa
epididymis secretory sperm binding protein
gal-1
galaptin
lactose-binding lectin 1
lectin, galactoside-binding, soluble, 1
putative MAPK-activating protein PM12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002305.4NP_002296.1  galectin-1

    See identical proteins and their annotated locations for NP_002296.1

    Status: REVIEWED

    Source sequence(s)
    BC020675
    Consensus CDS
    CCDS13954.1
    UniProtKB/Swiss-Prot
    P09382
    Related
    ENSP00000215909.5, ENST00000215909.9
    Conserved Domains (1) summary
    smart00276
    Location:11134
    GLECT; Galectin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    37675606..37679802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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