LGALS1 galectin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LGALS1provided by HGNC
Official Full Name: galectin 1provided by HGNC
Primary source: HGNC:HGNC:6561
See related: Ensembl:ENSG00000100097 MIM:150570
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GBP; GAL1
Summary: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Expression: Broad expression in fat (RPKM 642.6), endometrium (RPKM 479.1) and 23 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 22q13.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109.20200522	current	GRCh38.p13 (GCF_000001405.39)	22	NC_000022.11 (37675636..37679802)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (38071613..38075809)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High LGALS1 expression is associated with malignant peripheral nerve sheath tumors.
Title: Galectin-1 inhibition induces cell apoptosis through dual suppression of CXCR4 and Ras pathways in human malignant peripheral nerve sheath tumors.
our results demonstrate that RACK1 stimulates tumor invasion and lymph node metastasis of cervical cancer via galectin-1 and imply that targeting RACK1/galectin-1 axis provides promising means for cervical cancer treatment.
Title: RACK1 promotes the invasive activities and lymph node metastasis of cervical cancer via galectin-1.
Both Galectin-1 and -9 were associated with the occurrence of endometrial carcinoma and its pathological behavior and lymph node metastasis. High expression of Galectin-1 suggests a poor prognosis, whereas high expression of Galectin-9 was associated with early pathological changes.
Title: The Significance of Galectin-1 and Galectin-9 Expression in Endometrial Carcinoma.
levels of galectins-1 and -3 are significantly elevated in both Crohn's disease and ulcerative colitis patients compared to healthy people
Title: Serum galectins as potential biomarkers of inflammatory bowel diseases.
galectin-1 is overexpressed in the majority of thymic epithelial tumors
Title: Increased Galectin-1 Expression in Thymic Epithelial Tumors.
galectin-1 is a novel FOXP3- interacting protein, and that nuclear Gal-1 can interact with FOXP3 and dampen its tumor-suppressive effects in breast cancer.
Title: Nuclear galectin-1-FOXP3 interaction dampens the tumor-suppressive properties of FOXP3 in breast cancer.
presence in intervertebral disc correlated with degeneration
Title: Galectins-1 and -3 in Human Intervertebral Disc Degeneration: Non-Uniform Distribution Profiles and Activation of Disease Markers Involving NF-κB by Galectin-1.
High Gal-1 expression is associated with peripheral T-cell lymphomas.
Title: High intratumoural galectin-1 expression predicts adverse outcome in ALK<sup>-</sup> ALCL and CD30<sup>+</sup> PTCL-NOS.
Galectin-1 levels in cerebrospinal fluid were use to discriminate patients with Parkinsonism from controls.
Title: Cerebrospinal Fluid Galectin-1 Levels Discriminate Patients with Parkinsonism from Controls.
Gal-1 knockdown significantly inhibited CRPC cells' growth, anchorage-independent growth, migration, and invasion through the suppression of androgen receptor (AR) and Akt signaling. LLS30 targets Gal-1 as an allosteric inhibitor and decreases Gal-1-binding affinity to its binding partners. LLS30 showed in vivo efficacy in both AR-positive and AR-negative xenograft models.
Title: Targeting Galectin-1 Impairs Castration-Resistant Prostate Cancer Progression and Invasion.

Submit: New GeneRIF Correction See all GeneRIFs (327)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Galectin 1 binds to HIV-1 gp120 by recognizing clustered CX glycan patches of gp120 in a beta-galactoside-dependent manner. CD4 plays a role as a ligand for the binding between Galectin 1 and gp120	PubMed
	env	Galectin-1, a dimeric beta-galactoside-binding protein, promotes infection with CCR5-tropic, CXCR4-tropic, and CCR5/CXCR4 dual-tropic HIV-1 variants by facilitating attachment of HIV-1 gp120 to CD4 at the cell surface	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH48064 (e-PCR)
- UniSTS:4997

WI-18867 (e-PCR)
- UniSTS:12186

Homology

Homologs of the LGALS1 gene: The LGALS1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 284 organisms have orthologs with human gene LGALS1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
RNA binding	HDA more info	PubMed
carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
identical protein binding	IEA Inferred from Electronic Annotation more info
lactose binding	IEA Inferred from Electronic Annotation more info
laminin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
T cell costimulation	IEA Inferred from Electronic Annotation more info
apoptotic process	IEA Inferred from Electronic Annotation more info
cellular protein metabolic process	TAS Traceable Author Statement more info
cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
myoblast differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
plasma cell differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of I-kappaB kinase/NF-kappaB signaling	HMP more info	PubMed
NOT positive regulation of dendritic cell differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of erythrocyte aggregation	IEA Inferred from Electronic Annotation more info
positive regulation of viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed
post-translational protein modification	TAS Traceable Author Statement more info
regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
response to axon injury	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to isolation stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell surface	IEA Inferred from Electronic Annotation more info
collagen-containing extracellular matrix	HDA more info	PubMed
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
colocalizes_with collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cytoplasm	TAS Traceable Author Statement more info	PubMed
cytosol	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum lumen	TAS Traceable Author Statement more info
extracellular exosome	HDA more info	PubMed
extracellular region	HDA more info	PubMed
extracellular space	HDA more info	PubMed
extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
intracellular	IDA Inferred from Direct Assay more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: galectin-1

Names: 14 kDa laminin-binding protein; 14 kDa lectin; HBL; HLBP14; HPL; S-Lac lectin 1; beta-galactoside-binding lectin L-14-I; beta-galactoside-binding protein 14kDa; epididymis secretory sperm binding protein; gal-1; galaptin; lactose-binding lectin 1; lectin, galactoside-binding, soluble, 1; putative MAPK-activating protein PM12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.