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LGALS1 galectin 1 [ Homo sapiens (human) ]

Gene ID: 3956, updated on 6-Jul-2025
Official Symbol
LGALS1provided by HGNC
Official Full Name
galectin 1provided by HGNC
Primary source
HGNC:HGNC:6561
See related
Ensembl:ENSG00000100097 MIM:150570; AllianceGenome:HGNC:6561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBP; GAL1
Summary
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 642.6), endometrium (RPKM 479.1) and 23 other tissues See more
Orthologs
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See LGALS1 in Genome Data Viewer
Location:
22q13.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37675636..37679802)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38136888..38141054)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38071643..38075809)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38054605-38055106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38055933-38056444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38056445-38056955 Neighboring gene pyridoxal phosphatase Neighboring gene RNA, 7SL, cytoplasmic 385, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38073459-38074269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38077520-38078020 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38081369-38082310 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38082311-38083251 Neighboring gene nucleolar protein 12 Neighboring gene TRIO and F-actin binding protein Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38108187-38108370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38121829-38122330 Neighboring gene uncharacterized LOC124905115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38136652-38137169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38137170-38137686 Neighboring gene uncharacterized LOC102724378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13695

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Galectin 1 binds to HIV-1 gp120 by recognizing clustered CX glycan patches of gp120 in a beta-galactoside-dependent manner. CD4 plays a role as a ligand for the binding between Galectin 1 and gp120 PubMed
env Galectin-1, a dimeric beta-galactoside-binding protein, promotes infection with CCR5-tropic, CXCR4-tropic, and CCR5/CXCR4 dual-tropic HIV-1 variants by facilitating attachment of HIV-1 gp120 to CD4 at the cell surface PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • DKFZp686E23103

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables lactose binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell costimulation IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of T-helper 17 cell lineage commitment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T-helper 17 cell lineage commitment IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within plasma cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction HMP PubMed 
NOT involved_in positive regulation of dendritic cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
galectin-1
Names
14 kDa laminin-binding protein
14 kDa lectin
HBL
HLBP14
HPL
S-Lac lectin 1
beta-galactoside-binding lectin L-14-I
beta-galactoside-binding protein 14kDa
epididymis secretory sperm binding protein
gal-1
galaptin
lactose-binding lectin 1
lectin, galactoside-binding, soluble, 1
putative MAPK-activating protein PM12

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002305.4NP_002296.1  galectin-1

    See identical proteins and their annotated locations for NP_002296.1

    Status: REVIEWED

    Source sequence(s)
    BC020675
    Consensus CDS
    CCDS13954.1
    UniProtKB/Swiss-Prot
    B2R5E8, P09382, Q9UDK5
    UniProtKB/TrEMBL
    A0A384MR27
    Related
    ENSP00000215909.5, ENST00000215909.10
    Conserved Domains (1) summary
    smart00276
    Location:11134
    GLECT; Galectin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    37675636..37679802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    38136888..38141054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)