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NUDT19 nudix hydrolase 19 [ Homo sapiens (human) ]

Gene ID: 390916, updated on 6-Nov-2022

Summary

Official Symbol
NUDT19provided by HGNC
Official Full Name
nudix hydrolase 19provided by HGNC
Primary source
HGNC:HGNC:32036
See related
Ensembl:ENSG00000213965 AllianceGenome:HGNC:32036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RP2
Summary
Predicted to enable magnesium ion binding activity. Predicted to be involved in purine nucleoside bisphosphate metabolic process. Predicted to be located in cytosol and peroxisomal matrix. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 3.2), prostate (RPKM 2.7) and 25 other tissues See more
Orthologs
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Genomic context

See NUDT19 in Genome Data Viewer
Location:
19q13.11
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (32691821..32713792)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (35210556..35232527)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (33182727..33204698)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 27 Neighboring gene RNA, 7SL, cytoplasmic 789, pseudogene Neighboring gene uncharacterized LOC124904690 Neighboring gene regulator of G protein signaling 9 binding protein Neighboring gene tudor domain containing 12 Neighboring gene Sharpr-MPRA regulatory region 1108 Neighboring gene glial cells missing transcription factor 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CoA pyrophosphatase activity TAS
Traceable Author Statement
more info
 
enables acyl-coenzyme A diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in butyryl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in coenzyme A catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid catabolic process TAS
Traceable Author Statement
more info
 
involved_in malonyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in medium-chain fatty-acyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in propionyl-CoA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in succinyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
acyl-coenzyme A diphosphatase NUDT19
Names
CTC-379B2.4
nucleoside diphosphate-linked moiety X motif 19, mitochondrial
nudix (nucleoside diphosphate linked moiety X)-type motif 19
nudix motif 19
NP_001099040.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105570.2NP_001099040.1  acyl-coenzyme A diphosphatase NUDT19 precursor

    See identical proteins and their annotated locations for NP_001099040.1

    Status: VALIDATED

    Source sequence(s)
    AC008736
    Consensus CDS
    CCDS42543.1
    UniProtKB/Swiss-Prot
    A8MXV4
    Related
    ENSP00000380251.2, ENST00000397061.4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    32691821..32713792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    35210556..35232527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)