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LRRC26 leucine rich repeat containing 26 [ Homo sapiens (human) ]

Gene ID: 389816, updated on 27-Nov-2024

Summary

Official Symbol
LRRC26provided by HGNC
Official Full Name
leucine rich repeat containing 26provided by HGNC
Primary source
HGNC:HGNC:31409
See related
Ensembl:ENSG00000184709 MIM:613505; AllianceGenome:HGNC:31409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPC; bA350O14.10
Summary
Enables potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in prostate (RPKM 24.0), colon (RPKM 13.3) and 1 other tissue See more
Orthologs
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Genomic context

See LRRC26 in Genome Data Viewer
Location:
9q34.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (137168758..137170051, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149406438..149407731, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140063210..140064503, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20583 Neighboring gene Sharpr-MPRA regulatory region 8071 Neighboring gene glutamate ionotropic receptor NMDA type subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29346 Neighboring gene uncharacterized LOC105376328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:140057239-140057738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140062142-140063006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20587 Neighboring gene uncharacterized LOC124902315 Neighboring gene microRNA 3621 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140069251-140070084 Neighboring gene transmembrane protein 210 Neighboring gene anaphase promoting complex subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables potassium channel activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat-containing protein 26
Names
BK channel auxiliary gamma subunit LRRC26
BK channel auxilliary gamma subunit LRRC26
cytokeratin associated protein
cytokeratin-associated protein in cancer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013653.3NP_001013675.1  leucine-rich repeat-containing protein 26 precursor

    See identical proteins and their annotated locations for NP_001013675.1

    Status: VALIDATED

    Source sequence(s)
    AL929554
    Consensus CDS
    CCDS35184.1
    UniProtKB/Swiss-Prot
    B9EIR7, C3RUL3, Q2I0M4, Q5VSG2
    Related
    ENSP00000360597.3, ENST00000371542.3
    Conserved Domains (3) summary
    cd00116
    Location:97253
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:97120
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:97155
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    137168758..137170051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    149406438..149407731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)