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LAD1 ladinin 1 [ Homo sapiens (human) ]

Gene ID: 3898, updated on 1-Jun-2020

Summary

Official Symbol
LAD1provided by HGNC
Official Full Name
ladinin 1provided by HGNC
Primary source
HGNC:HGNC:6472
See related
Ensembl:ENSG00000159166 MIM:602314
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LadA
Summary
The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 94.2), skin (RPKM 74.3) and 10 other tissues See more
Orthologs

Genomic context

See LAD1 in Genome Data Viewer
Location:
1q32.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (201380833..201399324, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201349966..201368669, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929326 Neighboring gene troponin T2, cardiac type Neighboring gene skeletal muscle cis-regulatory module in TNNT2 intron Neighboring gene uncharacterized LOC101929343 Neighboring gene troponin I1, slow skeletal type

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC10355

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
basement membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
ladinin-1
Names
lad-1
linear IgA bullous dermatosis antigen
linear IgA disease antigen homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005558.4NP_005549.2  ladinin-1

    See identical proteins and their annotated locations for NP_005549.2

    Status: REVIEWED

    Source sequence(s)
    AC119427
    Consensus CDS
    CCDS1410.1
    UniProtKB/Swiss-Prot
    O00515
    Related
    ENSP00000375829.2, ENST00000391967.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    201380833..201399324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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