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GFRAL GDNF family receptor alpha like [ Homo sapiens (human) ]

Gene ID: 389400, updated on 25-Jan-2022

Summary

Official Symbol
GFRALprovided by HGNC
Official Full Name
GDNF family receptor alpha likeprovided by HGNC
Primary source
HGNC:HGNC:32789
See related
Ensembl:ENSG00000187871 MIM:617837; AllianceGenome:HGNC:32789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRAL; UNQ9356; C6orf144; bA360D14.1
Summary
Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in glial cell-derived neurotrophic factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of protein kinase B signaling. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GFRAL in Genome Data Viewer
Location:
6p12.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (55327469..55402493)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (55192267..55267291)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2673 Neighboring gene family with sequence similarity 83 member B Neighboring gene hypocretin receptor 2 Neighboring gene 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 Neighboring gene Sharpr-MPRA regulatory region 3486 Neighboring gene bone morphogenetic protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glial cell-derived neurotrophic factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GDNF family receptor alpha-like
Names
IVFI9356

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207410.2NP_997293.2  GDNF family receptor alpha-like precursor

    See identical proteins and their annotated locations for NP_997293.2

    Status: VALIDATED

    Source sequence(s)
    AL592426, AY358198
    Consensus CDS
    CCDS4957.1
    UniProtKB/Swiss-Prot
    Q6UXV0
    Related
    ENSP00000343636.2, ENST00000340465.2
    Conserved Domains (1) summary
    pfam02351
    Location:131210
    GDNF; GDNF/GAS1 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    55327469..55402493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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