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Gfral GDNF family receptor alpha like [ Mus musculus (house mouse) ]

Gene ID: 404194, updated on 8-Feb-2024

Summary

Official Symbol
Gfralprovided by MGI
Official Full Name
GDNF family receptor alpha likeprovided by MGI
Primary source
MGI:MGI:3607786
See related
Ensembl:ENSMUSG00000059383 AllianceGenome:MGI:3607786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gral
Summary
Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in positive regulation of MAPK cascade and reduction of food intake in response to dietary excess. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and stress-activated protein kinase signaling cascade. Located in plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Gfral in Genome Data Viewer
Location:
9 D; 9 42.48 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (76071389..76120939, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (76164102..76213657, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:75851566-75851867 Neighboring gene predicted gene, 34005 Neighboring gene STARR-seq mESC enhancer starr_24677 Neighboring gene 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 Neighboring gene STARR-seq mESC enhancer starr_24678 Neighboring gene STARR-seq mESC enhancer starr_24679 Neighboring gene STARR-positive B cell enhancer mm9_chr9:76084472-76084773 Neighboring gene hypocretin (orexin) receptor 2 Neighboring gene STARR-seq mESC enhancer starr_24681 Neighboring gene STARR-seq mESC enhancer starr_24685 Neighboring gene STARR-seq mESC enhancer starr_24686 Neighboring gene STARR-seq mESC enhancer starr_24687 Neighboring gene family with sequence similarity 83, member B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glial cell-derived neurotrophic factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glial cell-derived neurotrophic factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
GDNF family receptor alpha-like
Names
GDNF receptor alpha-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205844.4NP_995316.2  GDNF family receptor alpha-like precursor

    See identical proteins and their annotated locations for NP_995316.2

    Status: VALIDATED

    Source sequence(s)
    AC079244
    Consensus CDS
    CCDS40694.1
    UniProtKB/Swiss-Prot
    Q6SJD9, Q6SJE0
    Related
    ENSMUSP00000074421.6, ENSMUST00000074880.6
    Conserved Domains (1) summary
    pfam02351
    Location:131210
    GDNF; GDNF/GAS1 domain

RNA

  1. NR_153419.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079244
    Related
    ENSMUST00000184693.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    76071389..76120939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)