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SHISA2 shisa family member 2 [ Homo sapiens (human) ]

Gene ID: 387914, updated on 13-Mar-2020

Summary

Official Symbol
SHISA2provided by HGNC
Official Full Name
shisa family member 2provided by HGNC
Primary source
HGNC:HGNC:20366
See related
Ensembl:ENSG00000180730 MIM:617324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM46; hShisa; C13orf13; PRO28631; WGAR9166; bA398O19.2
Expression
Biased expression in thyroid (RPKM 17.4), lung (RPKM 4.1) and 3 other tissues See more
Orthologs

Genomic context

See SHISA2 in Genome Data Viewer
Location:
13q12.13
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (26044597..26052016, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (26618735..26625198, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8A2 Neighboring gene uncharacterized LOC105370122 Neighboring gene RNY1 pseudogene 3 Neighboring gene long intergenic non-protein coding RNA 415 Neighboring gene ATPase phospholipid transporting 8A2 pseudogene 3 Neighboring gene prune exopolyphosphatase pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of shisa homolog 2 (SHISA2; TMEM46) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein shisa-2 homolog
Names
shisa homolog 2
transmembrane protein 46

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007538.2NP_001007539.1  protein shisa-2 homolog precursor

    See identical proteins and their annotated locations for NP_001007539.1

    Status: VALIDATED

    Source sequence(s)
    AL139004
    Consensus CDS
    CCDS31951.1
    UniProtKB/Swiss-Prot
    Q6UWI4
    Related
    ENSP00000313079.2, ENST00000319420.3
    Conserved Domains (1) summary
    pfam13908
    Location:35167
    Shisa; Wnt and FGF inhibitory regulator

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    26044597..26052016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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