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SHISA2 shisa family member 2 [ Homo sapiens (human) ]

Gene ID: 387914, updated on 27-Nov-2024

Summary

Official Symbol
SHISA2provided by HGNC
Official Full Name
shisa family member 2provided by HGNC
Primary source
HGNC:HGNC:20366
See related
Ensembl:ENSG00000180730 MIM:617324; AllianceGenome:HGNC:20366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM46; hShisa; C13orf13; PRO28631; WGAR9166; bA398O19.2
Summary
Predicted to be involved in negative regulation of Wnt signaling pathway and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thyroid (RPKM 17.4), lung (RPKM 4.1) and 3 other tissues See more
Orthologs
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Genomic context

See SHISA2 in Genome Data Viewer
Location:
13q12.13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (26044597..26052016, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (25258479..25265905, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (26618735..26626154, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8A2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:26548551-26549090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:26549091-26549629 Neighboring gene uncharacterized LOC105370122 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:26550993-26551936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:26552889-26553440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:26585998-26586498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:26586499-26586999 Neighboring gene RNY1 pseudogene 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:26650935-26651149 Neighboring gene long intergenic non-protein coding RNA 415 Neighboring gene NANOG hESC enhancer GRCh37_chr13:26673008-26673509 Neighboring gene ATPase phospholipid transporting 8A2 pseudogene 3 Neighboring gene PRUNE1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of shisa homolog 2 (SHISA2; TMEM46) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein shisa-2 homolog
Names
shisa homolog 2
transmembrane protein 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007538.2NP_001007539.1  protein shisa-2 homolog precursor

    See identical proteins and their annotated locations for NP_001007539.1

    Status: VALIDATED

    Source sequence(s)
    AL139004
    Consensus CDS
    CCDS31951.1
    UniProtKB/Swiss-Prot
    B9EH70, Q5W0G8, Q6UWI4
    Related
    ENSP00000313079.3, ENST00000319420.4
    Conserved Domains (1) summary
    pfam13908
    Location:35167
    Shisa; Wnt and FGF inhibitory regulator

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    26044597..26052016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    25258479..25265905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)