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KRT17 keratin 17 [ Homo sapiens (human) ]

Gene ID: 3872, updated on 3-May-2020

Summary

Official Symbol
KRT17provided by HGNC
Official Full Name
keratin 17provided by HGNC
Primary source
HGNC:HGNC:6427
See related
Ensembl:ENSG00000128422 MIM:148069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PC; K17; PC2; 39.1; CK-17; PCHC1
Summary
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
Expression
Biased expression in urinary bladder (RPKM 147.9), skin (RPKM 53.6) and 3 other tissues See more
Orthologs

Genomic context

See KRT17 in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41619442..41624575, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39775692..39780882, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 14 Neighboring gene keratin 16 Neighboring gene keratin 42 pseudogene Neighboring gene eukaryotic translation initiation factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of keratin 17 (KRT17) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
hair follicle morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
intermediate filament organization IEA
Inferred from Electronic Annotation
more info
 
keratinization TAS
Traceable Author Statement
more info
 
positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell periphery IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
keratin, type I cytoskeletal 17
Names
cytokeratin-17
keratin 17, type I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008625.1 RefSeqGene

    Range
    5056..10189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000422.3NP_000413.1  keratin, type I cytoskeletal 17

    See identical proteins and their annotated locations for NP_000413.1

    Status: REVIEWED

    Source sequence(s)
    BC011901, BP226061
    Consensus CDS
    CCDS11402.1
    UniProtKB/Swiss-Prot
    Q04695
    UniProtKB/TrEMBL
    Q14666
    Related
    ENSP00000308452.8, ENST00000311208.13
    Conserved Domains (3) summary
    pfam00038
    Location:84394
    Filament; Intermediate filament protein
    cl03075
    Location:350403
    GrpE; nucleotide exchange factor GrpE
    cl14876
    Location:215296
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41619442..41624575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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