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KLC1 kinesin light chain 1 [ Homo sapiens (human) ]

Gene ID: 3831, updated on 13-Jan-2020

Summary

Official Symbol
KLC1provided by HGNC
Official Full Name
kinesin light chain 1provided by HGNC
Primary source
HGNC:HGNC:6387
See related
Ensembl:ENSG00000126214 MIM:600025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLC; KNS2; KNS2A
Summary
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 108.4), heart (RPKM 21.0) and 23 other tissues See more
Orthologs

Genomic context

See KLC1 in Genome Data Viewer
Location:
14q32.33
Exon count:
18
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (103629188..103701551)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104095525..104167888)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 68, pseudogene Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene uncharacterized LOC105370688 Neighboring gene uncharacterized LOC112268131 Neighboring gene uncharacterized LOC107984648 Neighboring gene X-ray repair cross complementing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: COA8

Homology

Clone Names

  • MGC15245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
motor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
microtubule-based movement TAS
Traceable Author Statement
more info
 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
stress granule disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
kinesin complex ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane HDA PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinesin light chain 1
Names
kinesin 2 60/70kDa
medulloblastoma antigen MU-MB-2.50
NP_001123579.1
NP_005543.2
NP_891553.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012307.1 RefSeqGene

    Range
    5001..77364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130107.1NP_001123579.1  kinesin light chain 1 isoform 3

    See identical proteins and their annotated locations for NP_001123579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3, also known as D.
    Source sequence(s)
    BC008881, BK001163, BK001164, BM988840, BP274336
    Consensus CDS
    CCDS45168.1
    UniProtKB/Swiss-Prot
    Q07866
    UniProtKB/TrEMBL
    Q7RTQ2
    Related
    ENSP00000414982.2, ENST00000452929.6
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:35149
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_005552.4NP_005543.2  kinesin light chain 1 isoform 1

    See identical proteins and their annotated locations for NP_005543.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 3' sequence, as compared to variant 3. The resulting isoform (1, also known as C) has a shorter and distinct C-terminus, as compared to isoform 3.
    Source sequence(s)
    AL049840, BC008881, BP274336, CB050619, DA501532
    Consensus CDS
    CCDS32165.1
    UniProtKB/Swiss-Prot
    Q07866
    Related
    ENSP00000374394.3, ENST00000389744.8
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:35149
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_182923.3NP_891553.2  kinesin light chain 1 isoform 2

    See identical proteins and their annotated locations for NP_891553.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a coding exon in the 3' region, as compared to variant 3. The resulting isoform (2, also known as H) has a shorter and distinct C-terminus when compared to isoform 3.
    Source sequence(s)
    AL139300, BM988840, BP274336, L04733
    Consensus CDS
    CCDS41996.1
    UniProtKB/Swiss-Prot
    Q07866
    Related
    ENSP00000341154.6, ENST00000348520.10
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:296337
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:293370
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    103629188..103701551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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