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KLC1 kinesin light chain 1 [ Homo sapiens (human) ]

Gene ID: 3831, updated on 22-May-2022

Summary

Official Symbol
KLC1provided by HGNC
Official Full Name
kinesin light chain 1provided by HGNC
Primary source
HGNC:HGNC:6387
See related
Ensembl:ENSG00000126214 MIM:600025; AllianceGenome:HGNC:6387
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLC; KNS2; KNS2A
Summary
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 108.4), heart (RPKM 21.0) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KLC1 in Genome Data Viewer
Location:
14q32.33
Exon count:
20
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103629211..103701544)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97865285..97937591)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104095548..104167881)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 68, pseudogene Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene uncharacterized LOC105370688 Neighboring gene X-ray repair cross complementing 3 Neighboring gene zinc finger FYVE-type containing 21 Neighboring gene protein phosphatase 1 regulatory subunit 13B Neighboring gene small nucleolar RNA SNORD51

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: COA8

Homology

Clone Names

  • MGC15245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
PubMed 
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in stress granule disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of kinesin complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane HDA PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinesin light chain 1
Names
kinesin 2 60/70kDa
medulloblastoma antigen MU-MB-2.50
NP_001123579.1
NP_001381761.1
NP_001381762.1
NP_001381763.1
NP_001381764.1
NP_001381765.1
NP_001381766.1
NP_001381767.1
NP_001381768.1
NP_001381769.1
NP_001381770.1
NP_001381771.1
NP_001381772.1
NP_001381773.1
NP_001381774.1
NP_001381775.1
NP_001381776.1
NP_001381777.1
NP_001381778.1
NP_001381779.1
NP_001381780.1
NP_001381781.1
NP_001381782.1
NP_001381783.1
NP_001381784.1
NP_001381785.1
NP_001381786.1
NP_001381787.1
NP_001381788.1
NP_001381789.1
NP_005543.2
NP_891553.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012307.1 RefSeqGene

    Range
    5001..77364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130107.2NP_001123579.1  kinesin light chain 1 isoform 3

    See identical proteins and their annotated locations for NP_001123579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3, also known as D.
    Source sequence(s)
    BC008881, BK001163, BK001164, BM988840, BP274336
    Consensus CDS
    CCDS45168.1
    UniProtKB/Swiss-Prot
    Q07866
    UniProtKB/TrEMBL
    Q7RTQ2
    Related
    ENSP00000414982.2, ENST00000452929.6
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  2. NM_001394832.1NP_001381761.1  kinesin light chain 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  3. NM_001394833.1NP_001381762.1  kinesin light chain 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  4. NM_001394834.1NP_001381763.1  kinesin light chain 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  5. NM_001394835.1NP_001381764.1  kinesin light chain 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  6. NM_001394836.1NP_001381765.1  kinesin light chain 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  7. NM_001394837.1NP_001381766.1  kinesin light chain 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Related
    ENSP00000334523.6, ENST00000334553.11
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  8. NM_001394838.1NP_001381767.1  kinesin light chain 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Related
    ENSP00000246489.7, ENST00000246489.11
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  9. NM_001394839.1NP_001381768.1  kinesin light chain 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  10. NM_001394840.1NP_001381769.1  kinesin light chain 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Related
    ENSP00000452481.1, ENST00000555836.5
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  11. NM_001394841.1NP_001381770.1  kinesin light chain 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Related
    ENSP00000334618.7, ENST00000347839.10
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  12. NM_001394842.1NP_001381771.1  kinesin light chain 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:296324
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:295369
    TPR_12; Tetratricopeptide repeat
  13. NM_001394843.1NP_001381772.1  kinesin light chain 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294368
    TPR_12; Tetratricopeptide repeat
  14. NM_001394844.1NP_001381773.1  kinesin light chain 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Related
    ENSP00000451242.1, ENST00000554280.5
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  15. NM_001394845.1NP_001381774.1  kinesin light chain 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  16. NM_001394846.1NP_001381775.1  kinesin light chain 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  17. NM_001394847.1NP_001381776.1  kinesin light chain 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  18. NM_001394848.1NP_001381777.1  kinesin light chain 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  19. NM_001394849.1NP_001381778.1  kinesin light chain 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  20. NM_001394850.1NP_001381779.1  kinesin light chain 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Related
    ENSP00000369377.3, ENST00000380038.7
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  21. NM_001394851.1NP_001381780.1  kinesin light chain 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294368
    TPR_12; Tetratricopeptide repeat
  22. NM_001394852.1NP_001381781.1  kinesin light chain 1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Related
    ENSP00000450648.1, ENST00000557450.5
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  23. NM_001394853.1NP_001381782.1  kinesin light chain 1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  24. NM_001394854.1NP_001381783.1  kinesin light chain 1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  25. NM_001394855.1NP_001381784.1  kinesin light chain 1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  26. NM_001394856.1NP_001381785.1  kinesin light chain 1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  27. NM_001394857.1NP_001381786.1  kinesin light chain 1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Related
    ENSP00000412693.4, ENST00000445352.8
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294368
    TPR_12; Tetratricopeptide repeat
  28. NM_001394858.1NP_001381787.1  kinesin light chain 1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Related
    ENSP00000488938.1, ENST00000634686.1
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  29. NM_001394859.1NP_001381788.1  kinesin light chain 1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  30. NM_001394860.1NP_001381789.1  kinesin light chain 1 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AL049840, AL139300
    Related
    ENSP00000450617.1, ENST00000557575.5
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  31. NM_005552.5NP_005543.2  kinesin light chain 1 isoform 1

    See identical proteins and their annotated locations for NP_005543.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 3' sequence, as compared to variant 3. The resulting isoform (1, also known as C) has a shorter and distinct C-terminus, as compared to isoform 3.
    Source sequence(s)
    AL049840, BC008881, DA501532
    Consensus CDS
    CCDS32165.1
    UniProtKB/Swiss-Prot
    Q07866
    Related
    ENSP00000374394.3, ENST00000389744.8
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:35149
    SMC_N; RecF/RecN/SMC N terminal domain
  32. NM_182923.4NP_891553.2  kinesin light chain 1 isoform 2

    See identical proteins and their annotated locations for NP_891553.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a coding exon in the 3' region, as compared to variant 3. The resulting isoform (2, also known as H) has a shorter and distinct C-terminus when compared to isoform 3.
    Source sequence(s)
    AL139300, BM988840, BP274336, L04733
    Consensus CDS
    CCDS41996.1
    UniProtKB/Swiss-Prot
    Q07866
    Related
    ENSP00000341154.6, ENST00000348520.10
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    103629211..103701544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    97865285..97937591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)