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Klc1 kinesin light chain 1 [ Mus musculus (house mouse) ]

Gene ID: 16593, updated on 5-Jan-2023

Summary

Official Symbol
Klc1provided by MGI
Official Full Name
kinesin light chain 1provided by MGI
Primary source
MGI:MGI:107978
See related
Ensembl:ENSMUSG00000021288 AllianceGenome:MGI:107978
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kns2
Summary
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in frontal lobe adult (RPKM 53.0), CNS E18 (RPKM 52.5) and 26 other tissues See more
Orthologs
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Genomic context

See Klc1 in Genome Data Viewer
Location:
12 F1; 12 61.13 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111724869..111774278)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111758435..111807844)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36635 Neighboring gene BCL2-associated athanogene 5 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene zinc finger, FYVE domain containing 21 Neighboring gene protein phosphatase 1, regulatory subunit 13B Neighboring gene predicted gene, 53769

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within axo-dendritic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule-based movement TAS
Traceable Author Statement
more info
PubMed 
involved_in protein localization to synapse ISO
Inferred from Sequence Orthology
more info
 
involved_in stress granule disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary rootlet IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary rootlet IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
part_of kinesin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin light chain 1
Names
KLC 1
kinesin 2 60/70kDa
NP_001020529.2
NP_001020530.2
NP_001020531.2
NP_001020532.2
NP_001020533.2
NP_001020534.2
NP_001075428.1
NP_001348534.1
NP_001348538.1
NP_001348539.1
NP_001348540.1
NP_001348541.1
NP_001348542.1
NP_001348543.1
NP_032476.2
XP_006515557.1
XP_030102425.1
XP_030102426.1
XP_036013090.1
XP_036013091.1
XP_036013092.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025358.2NP_001020529.2  kinesin light chain 1 isoform 1B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) uses an alternate splice site and alternate exon in the 3' coding region and 3' UTR, compared to variant d. The resulting protein (isoform 1B) is shorter and has a distinct C-terminus, compared to isoform 1D.
    Source sequence(s)
    AA059822, BE946775, BG094009, BK000669, BU922789, BY014721, CF615940, CK620595, CV883867
    UniProtKB/TrEMBL
    Q7M702
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:296337
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:251329
    TPR_12; Tetratricopeptide repeat
  2. NM_001025359.2NP_001020530.2  kinesin light chain 1 isoform 1C

    See identical proteins and their annotated locations for NP_001020530.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) uses an alternate splice site and alternate exon in the 3' coding region and 3' UTR, compared to variant d. The resulting protein (isoform 1C) is shorter and has a distinct C-terminus, compared to isoform 1D.
    Source sequence(s)
    BB457558, BE946775, BG094009, BK000670, BY014721, CF615940, CK032061, W10467
    Consensus CDS
    CCDS70423.1
    UniProtKB/TrEMBL
    E9Q7C9, Q7M701
    Related
    ENSMUSP00000113237.3, ENSMUST00000120544.9
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:296337
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:251329
    TPR_12; Tetratricopeptide repeat
  3. NM_001025360.2NP_001020531.2  kinesin light chain 1 isoform 1D

    See identical proteins and their annotated locations for NP_001020531.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) represents the longest transcript and encodes the longest isoform (1D).
    Source sequence(s)
    AC152065, AK031309, AU035615
    Consensus CDS
    CCDS36565.1
    UniProtKB/TrEMBL
    Q8CD76
    Related
    ENSMUSP00000082004.6, ENSMUST00000084941.12
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:296337
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:251329
    TPR_12; Tetratricopeptide repeat
  4. NM_001025361.2NP_001020532.2  kinesin light chain 1 isoform 1E

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) uses an alternate in-frame splice site in the 3' coding region, compared to variant d. The resulting protein (isoform 1E) is shorter than isoform 1D.
    Source sequence(s)
    AV319299, BB835417, BG094009, BK000672, BU922789, BY014721, CF615940
    UniProtKB/TrEMBL
    Q7M6Z9
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:296337
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:251329
    TPR_12; Tetratricopeptide repeat
  5. NM_001025362.2NP_001020533.2  kinesin light chain 1 isoform 1G

    See identical proteins and their annotated locations for NP_001020533.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (g) uses an alternate splice site, lacks an alternate exon in the 3' coding region and 3' UTR, and has an alternate exon in the 3' UTR, compared to variant d. The resulting protein (isoform 1G) is shorter and has a distinct C-terminus, compared to isoform 1D.
    Source sequence(s)
    BG094009, BK000674, BU922789, BY014721, CF615940
    UniProtKB/TrEMBL
    Q7M6Z7
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  6. NM_001025363.2NP_001020534.2  kinesin light chain 1 isoform 1F

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) uses an alternate in-frame splice site and alternate exon in the 3' coding region and 3' UTR, compared to variant d. The resulting protein (isoform 1F) is shorter and has a distinct C-terminus, compared to isoform 1D.
    Source sequence(s)
    AA059822, BE946775, BG094009, BK000673, BY014721, CF615940, CK032061, CK620595, CV883867
    UniProtKB/TrEMBL
    Q7M6Z8
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:296337
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:251329
    TPR_12; Tetratricopeptide repeat
  7. NM_001081959.1NP_001075428.1  kinesin light chain 1 isoform 1H

    See identical proteins and their annotated locations for NP_001075428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (h) uses an alternate in-frame splice site in the 3' coding region, compared to variant d. The resulting protein (isoform 1H) is shorter than isoform 1D.
    Source sequence(s)
    AK031309, AU035615, BC055744
    Consensus CDS
    CCDS49183.1
    UniProtKB/TrEMBL
    Q7TNF4, Q8CD76
    Related
    ENSMUSP00000113997.2, ENSMUST00000122300.8
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:296337
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:251329
    TPR_12; Tetratricopeptide repeat
  8. NM_001361605.1NP_001348534.1  kinesin light chain 1 isoform 1I

    Status: REVIEWED

    Source sequence(s)
    AK031309, AU035615, BC055744, CN456461, CX734724
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:35149
    SMC_N; RecF/RecN/SMC N terminal domain
  9. NM_001361609.1NP_001348538.1  kinesin light chain 1 isoform 1J

    Status: REVIEWED

    Source sequence(s)
    AC152065, AK031309, AY753300, BC055744, BY783968
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:35149
    SMC_N; RecF/RecN/SMC N terminal domain
  10. NM_001361610.1NP_001348539.1  kinesin light chain 1 isoform 1K

    Status: REVIEWED

    Source sequence(s)
    AC152065, AK031309, BC055744, BY783968
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:35149
    SMC_N; RecF/RecN/SMC N terminal domain
  11. NM_001361611.1NP_001348540.1  kinesin light chain 1 isoform 1L

    Status: REVIEWED

    Source sequence(s)
    AC152065, BE946775
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:35149
    SMC_N; RecF/RecN/SMC N terminal domain
  12. NM_001361612.1NP_001348541.1  kinesin light chain 1 isoform 1M

    Status: REVIEWED

    Source sequence(s)
    AC152065, BE946775
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:35149
    SMC_N; RecF/RecN/SMC N terminal domain
  13. NM_001361613.1NP_001348542.1  kinesin light chain 1 isoform 1N

    Status: REVIEWED

    Source sequence(s)
    AC152065, BC055744, BE946775, BY783968, CD775356, CJ249676, CX734724
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:35149
    SMC_N; RecF/RecN/SMC N terminal domain
  14. NM_001361614.1NP_001348543.1  kinesin light chain 1 isoform 1O

    Status: REVIEWED

    Source sequence(s)
    AC152065, BC055744, BE946775, BY783968, CJ249676, CX734724
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:35149
    SMC_N; RecF/RecN/SMC N terminal domain
  15. NM_008450.2NP_032476.2  kinesin light chain 1 isoform 1A

    See identical proteins and their annotated locations for NP_032476.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) uses an alternate splice site and alternate exon in the 3' coding region and 3' UTR, compared to variant d. The resulting protein (isoform 1A) is shorter and has a distinct C-terminus, compared to isoform 1D.
    Source sequence(s)
    AU035615, BC055744, BE946775, CJ249676, CX734724
    Consensus CDS
    CCDS49182.1
    UniProtKB/TrEMBL
    Q5UE59, Q7TNF4
    Related
    ENSMUSP00000113171.2, ENSMUST00000118471.8
    Conserved Domains (3) summary
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:296337
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:251329
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111724869..111774278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157198.1XP_036013091.1  kinesin light chain 1 isoform X2

  2. XM_006515494.4XP_006515557.1  kinesin light chain 1 isoform X5

    See identical proteins and their annotated locations for XP_006515557.1

    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  3. XM_030246566.2XP_030102426.1  kinesin light chain 1 isoform X6

    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  4. XM_036157197.1XP_036013090.1  kinesin light chain 1 isoform X1

    UniProtKB/TrEMBL
    A0A5F8MPZ2
    Related
    ENSMUSP00000159193.2, ENSMUST00000239017.2
    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  5. XM_036157199.1XP_036013092.1  kinesin light chain 1 isoform X3

    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:297325
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:296370
    TPR_12; Tetratricopeptide repeat
  6. XM_030246565.2XP_030102425.1  kinesin light chain 1 isoform X4

    Conserved Domains (3) summary
    TIGR02168
    Location:35149
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:344372
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:342417
    TPR_12; Tetratricopeptide repeat

RNA

  1. XR_003949989.1 RNA Sequence

  2. XR_003949988.2 RNA Sequence

  3. XR_003949987.2 RNA Sequence

  4. XR_003949986.2 RNA Sequence