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Ifi211 interferon activated gene 211 [ Mus musculus (house mouse) ]

Gene ID: 381308, updated on 11-Apr-2024

Summary

Official Symbol
Ifi211provided by MGI
Official Full Name
interferon activated gene 211provided by MGI
Primary source
MGI:MGI:3041120
See related
Ensembl:ENSMUSG00000026536 AllianceGenome:MGI:3041120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mnda; Ifi205b; ifi-205-B; A730048F03
Summary
The protein encoded by this gene is a member of the interferon-regulated 200 family of proteins, which contain an N-terminal pyrin domain that is proposed to function in cell death and a partially conserved 220 amino acid domain. Expression of this protein in embryonic stem cells is critical for the DNA damage response and regulation of cell survival. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Expression
Broad expression in liver E18 (RPKM 4.0), bladder adult (RPKM 2.7) and 15 other tissues See more
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Genomic context

See Ifi211 in Genome Data Viewer
Location:
1 H3; 1 80.74 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173723907..173740650, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173896339..173913087, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03084 Neighboring gene myeloid nuclear differentiation antigen like Neighboring gene STARR-positive B cell enhancer ABC_E801 Neighboring gene predicted gene, 21031 Neighboring gene STARR-positive B cell enhancer ABC_E11108 Neighboring gene interferon activated gene 203 Neighboring gene STARR-positive B cell enhancer ABC_E3335 Neighboring gene STARR-positive B cell enhancer ABC_E11109 Neighboring gene interferon activated gene 202B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear periphery ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon-activable protein 205-B
Names
interferon-inducible protein p205-B
lipopolysaccharide-inducible
myeloid cell nuclear differentiation antigen
protein D3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033450.4NP_001028622.1  interferon-activable protein 205-B isoform 1

    See identical proteins and their annotated locations for NP_001028622.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC170584, AK152683, AK166217, AV250999, CJ067068
    Consensus CDS
    CCDS15532.1
    UniProtKB/Swiss-Prot
    P0DOV1
    UniProtKB/TrEMBL
    A0A1Z3MI21
    Related
    ENSMUSP00000009340.9, ENSMUST00000009340.10
    Conserved Domains (2) summary
    cd08305
    Location:1083
    Pyrin; Pyrin: a protein-protein interaction domain
    pfam02760
    Location:225393
    HIN; HIN-200/IF120x domain
  2. NM_001301745.1NP_001288674.1  interferon-activable protein 205-B isoform 2

    See identical proteins and their annotated locations for NP_001288674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC170584, AK080485, AK152683, AK166217, AV250999, CJ067068
    UniProtKB/TrEMBL
    A0A1Z3MI21
    Conserved Domains (2) summary
    cd08305
    Location:1083
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:223391
    HIN; HIN-200/IF120x domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    173723907..173740650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166133.1XP_036022026.1  interferon-activable protein 205-B isoform X1

    Conserved Domains (1) summary
    cd08305
    Location:1083
    Pyrin; a protein-protein interaction domain