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KIR2DS5 killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 [ Homo sapiens (human) ]

Gene ID: 3810, updated on 11-Jun-2021

Summary

Official Symbol
KIR2DS5provided by HGNC
Official Full Name
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5provided by HGNC
Primary source
HGNC:HGNC:6337
See related
MIM:604956
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKAT9; CD158G
Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Annotation information
Annotation category: only annotated on alternate loci and patches unit in reference assembly
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Genomic context

See KIR2DS5 in Genome Data Viewer
Location:
19q13.4
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_35) NT_113949.2 (29858..44878, complement)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_18) NT_187644.1 (36929..51949, complement)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_20) NT_187668.1 (105956..120932, complement)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_31) NT_187684.1 (117552..132589, complement)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_33) NT_187686.1 (116409..131427, complement)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_2) NW_003571055.2 (462371..477391)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (PATCHES) NW_016107303.1 (251523..266543)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (PATCHES) NW_016107304.1 (146132..161159)
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 (PATCHES) NW_016107312.1 (79881..94902, complement)

NT_187644.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1

NW_003571055.2Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

NT_187668.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 Neighboring gene uncharacterized LOC101928804 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2

NT_187684.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 Neighboring gene uncharacterized LOC101928804 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3

NT_187686.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 Neighboring gene uncharacterized LOC101928804 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains pseudogene 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2

NT_113949.2Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1

NW_016107312.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

NW_016107304.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

NW_016107303.1Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains pseudogene 1-like Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables HLA-C specific inhibitory MHC class I receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in innate immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
killer cell immunoglobulin-like receptor 2DS5
Names
CD158 antigen-like family member G
NKAT-9
killer Ig receptor
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
natural killer cell inhibitory receptor
natural killer-associated transcript 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_005994.1 

    Range
    164970..179990
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014513.2NP_055328.2  killer cell immunoglobulin-like receptor 2DS5 precursor

    See identical proteins and their annotated locations for NP_055328.2

    Status: REVIEWED

    Source sequence(s)
    AF208054
    Conserved Domains (2) summary
    cd00096
    Location:2933
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28122
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107303.1 Reference GRCh38.p13 PATCHES

    Range
    251523..266543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107304.1 Reference GRCh38.p13 PATCHES

    Range
    146132..161159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107312.1 Reference GRCh38.p13 PATCHES

    Range
    79881..94902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    462371..477391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_18

Genomic

  1. NT_187644.1 Reference GRCh38.p13 ALT_REF_LOCI_18

    Range
    36929..51949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_20

Genomic

  1. NT_187668.1 Reference GRCh38.p13 ALT_REF_LOCI_20

    Range
    105956..120932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_31

Genomic

  1. NT_187684.1 Reference GRCh38.p13 ALT_REF_LOCI_31

    Range
    117552..132589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_33

Genomic

  1. NT_187686.1 Reference GRCh38.p13 ALT_REF_LOCI_33

    Range
    116409..131427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_35

Genomic

  1. NT_113949.2 Reference GRCh38.p13 ALT_REF_LOCI_35

    Range
    29858..44878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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