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Zfp395 zinc finger protein 395 [ Mus musculus (house mouse) ]

Gene ID: 380912, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp395provided by MGI
Official Full Name
zinc finger protein 395provided by MGI
Primary source
MGI:MGI:2682318
See related
Ensembl:ENSMUSG00000034522 AllianceGenome:MGI:2682318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm910
Summary
Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including aorta; brain; endocrine gland; gallbladder; and reproductive system. Orthologous to human ZNF395 (zinc finger protein 395). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 20.0), ovary adult (RPKM 19.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp395 in Genome Data Viewer
Location:
14 D1; 14 34.32 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65595796..65636379)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65358676..65398930)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene frizzled class receptor 3 Neighboring gene STARR-seq mESC enhancer starr_36966 Neighboring gene predicted gene, 52141 Neighboring gene F-box protein 16 Neighboring gene STARR-seq mESC enhancer starr_36967 Neighboring gene predicted gene, 41178 Neighboring gene STARR-positive B cell enhancer ABC_E4114 Neighboring gene STARR-positive B cell enhancer ABC_E3120 Neighboring gene predicted gene, 48449 Neighboring gene STARR-seq mESC enhancer starr_36972 Neighboring gene STARR-positive B cell enhancer mm9_chr14:66008600-66008901 Neighboring gene prepronociceptin Neighboring gene RIKEN cDNA 9530047P18 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel MyoD enhancer-binding factor. Yamamoto M, et al. Mech Dev, 2007 Sep-Oct. PMID 17693064, Free PMC Article
  2. Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism. Shang Y, et al. PLoS Biol, 2013. PMID 23565059, Free PMC Article
  3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Clone Names

  • MGC60757

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 395
Names
papillomavirus regulatory factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199029.2 → NP_950194.2  zinc finger protein 395

    See identical proteins and their annotated locations for NP_950194.2

    Status: VALIDATED

    Source sequence(s)
    AC158983, AI425685, BY117447, BY780785, CF737135
    Consensus CDS
    CCDS49522.1
    UniProtKB/TrEMBL
    E9Q5N9, Q3U227
    Related
    ENSMUSP00000064422.7, ENSMUST00000066994.7
    Conserved Domains (1) summary
    pfam15997
    Location:4 → 110
    DUF4772; Domain of unknown function (DUF4772)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    65595796..65636379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158689.1 → XP_036014582.1  zinc finger protein 395 isoform X1

    UniProtKB/TrEMBL
    E9Q5N9, Q3U227
    Conserved Domains (1) summary
    pfam15997
    Location:4 → 110
    DUF4772; Domain of unknown function (DUF4772)

  2. XM_011245097.3 → XP_011243399.1  zinc finger protein 395 isoform X1

    See identical proteins and their annotated locations for XP_011243399.1

    UniProtKB/TrEMBL
    E9Q5N9, Q3U227
    Conserved Domains (1) summary
    pfam15997
    Location:4 → 110
    DUF4772; Domain of unknown function (DUF4772)
Nucleotide Protein Strain
Heading Accession and Version

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