invs.S inversin S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: invs.S
Official Full Name: inversin S homeolog
Primary source: Xenbase:XB-GENE-1221139
Locus tag: XELAEV_18041691mg
See related: EnsemblRapid:ENSXLAG00005014919
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: NPH2; inv1; invs; NPHP2; invs-1; invs-a; invs-b; invs.L
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Genomic context

Location:: chromosome: 8S

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8S	NC_054386.1 (34959457..34962758, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8S	NC_030739.1 (34665276..34668577, complement)

Chromosome 8S - NC_054386.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inversin relays Frizzled-8 signals to promote proximal pronephros development.
Title: Inversin relays Frizzled-8 signals to promote proximal pronephros development.
The present study indicates that calmodulin binding sites (IQ motifs) are crucial in controlling the biological activity of both mouse and Xenopus inv proteins
Title: Isolation and characterization of Xenopus laevis homologs of the mouse inv gene and functional analysis of the conserved calmodulin binding sites.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to ciliary inversin compartment	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ciliary inversin compartment	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inversin-A

Names: inversin L homeolog; nephrocystin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085761.1 → NP_001079230.1 inversin-A

See identical proteins and their annotated locations for NP_001079230.1

Status: PROVISIONAL

Source sequence(s)

AF321228

UniProtKB/Swiss-Prot

Q71S22, Q8UVC0

UniProtKB/TrEMBL

A0A974C394, B7ZSA6

Related

ENSXLAP00005043695.1, ENSXLAT00005044766.1

Conserved Domains (4) summary

cd00204
Location:380 → 505

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:390 → 482

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:181 → 236

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:418 → 449

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

34959457..34962758 complement

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GenBank, FASTA, Sequence Viewer (Graphics)