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LRRC37A3 leucine rich repeat containing 37 member A3 [ Homo sapiens (human) ]

Gene ID: 374819, updated on 25-Nov-2025
Official Symbol
LRRC37A3provided by HGNC
Official Full Name
leucine rich repeat containing 37 member A3provided by HGNC
Primary source
HGNC:HGNC:32427
See related
Ensembl:ENSG00000176809 MIM:616557; AllianceGenome:HGNC:32427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC37; LRRC37A
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in testis (RPKM 11.0), thyroid (RPKM 2.4) and 22 other tissues See more
Orthologs
all
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See LRRC37A3 in Genome Data Viewer
Location:
17q24.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (64854130..64919478, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (65723888..65789435, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62850248..62915596, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene pleckstrin homology and RUN domain containing M1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62821718-62822218 Neighboring gene RNA, U7 small nuclear 115 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8852 Neighboring gene uncharacterized LOC105371860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12601 Neighboring gene uncharacterized LOC105376844 Neighboring gene ARF like GTPase 17A pseudogene Neighboring gene RNA, 7SL, cytoplasmic 404, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8853 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:62915421-62915921 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62915997-62916498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62916499-62916998 Neighboring gene RDM1 pseudogene 4 Neighboring gene Sharpr-MPRA regulatory region 3243 Neighboring gene uncharacterized LOC107985000 Neighboring gene SLC16A6 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12602 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:62962191-62962354 Neighboring gene Sharpr-MPRA regulatory region 14154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8856 Neighboring gene AMZ2 pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region. Bekpen C, et al. Genome Res, 2012 Jun. PMID 22419166, Free PMC Article
  2. Evolutionary dynamism of the primate LRRC37 gene family. Giannuzzi G, et al. Genome Res, 2013 Jan. PMID 23064749, Free PMC Article
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Feb 28. PMID 9628581
  4. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
  5. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Antoniali G, et al. Nat Commun, 2017 Oct 6. PMID 28986522, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ34306, FLJ42521, KIAA0563, MGC41826, MGC57168

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
leucine-rich repeat-containing protein 37A3
NP_955372.2

Length

  • 1634

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054749.1 RefSeqGene

    Range
    51751..117099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001303255.3 → NP_001290184.1  leucine-rich repeat-containing protein 37A3 isoform 2

    See identical proteins and their annotated locations for NP_001290184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks four exons in the 5' region and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC103810, AK294371, AK315945, BI560889
    Consensus CDS
    CCDS77091.1
    UniProtKB/TrEMBL
    B4DG20, J3QTJ5
    Related
    ENSP00000344298.5, ENST00000339474.9
    Conserved Domains (3) summary
    sd00031
    Location:60 → 83
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:61 → 113
    LRR_8; Leucine rich repeat
    pfam14914
    Location:586 → 708
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain

  2. NM_199340.5 → NP_955372.2  leucine-rich repeat-containing protein 37A3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_955372.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB011135, AC103810, AK294371, AK315945, BI560889
    Consensus CDS
    CCDS32708.1
    UniProtKB/Swiss-Prot
    O60309, Q49A01, Q49A80, Q8NB33
    UniProtKB/TrEMBL
    A0A0G2JRB3
    Related
    ENSP00000464535.1, ENST00000584306.6
    Conserved Domains (5) summary
    sd00031
    Location:891 → 914
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892 → 929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892 → 949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:1468 → 1590
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    64854130..64919478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1233078..1569269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    197796..287327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    65723888..65789435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60309.2 GenPept UniProtKB/Swiss-Prot:O60309

Gene LinkOut

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