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LRRC37A3 leucine rich repeat containing 37 member A3 [ Homo sapiens (human) ]

Gene ID: 374819, updated on 11-Jun-2021

Summary

Official Symbol
LRRC37A3provided by HGNC
Official Full Name
leucine rich repeat containing 37 member A3provided by HGNC
Primary source
HGNC:HGNC:32427
See related
Ensembl:ENSG00000176809 MIM:616557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC37; LRRC37A
Expression
Broad expression in testis (RPKM 11.0), thyroid (RPKM 2.4) and 22 other tissues See more
Orthologs
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Genomic context

See LRRC37A3 in Genome Data Viewer
Location:
17q24.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (64854130..64919478, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62850248..62915596, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene pleckstrin homology and RUN domain containing M1 pseudogene 1 Neighboring gene RNA, U7 small nuclear 115 pseudogene Neighboring gene uncharacterized LOC105376844 Neighboring gene uncharacterized LOC105371860 Neighboring gene ADP ribosylation factor like GTPase 17A pseudogene Neighboring gene RNA, 7SL, cytoplasmic 404, pseudogene Neighboring gene RDM1 pseudogene 4 Neighboring gene uncharacterized LOC107985000 Neighboring gene SLC16A6 pseudogene 1 Neighboring gene AMZ2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34306, FLJ42521, KIAA0563, MGC41826, MGC57168

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 37A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054749.1 RefSeqGene

    Range
    51738..117095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001303255.3NP_001290184.1  leucine-rich repeat-containing protein 37A3 isoform 2

    See identical proteins and their annotated locations for NP_001290184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks four exons in the 5' region and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC103810, AK294371, AK315945, BI560889
    Consensus CDS
    CCDS77091.1
    UniProtKB/TrEMBL
    J3QTJ5
    Related
    ENSP00000344298.5, ENST00000339474.9
    Conserved Domains (4) summary
    sd00031
    Location:6083
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:83125
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:61113
    LRR_8; Leucine rich repeat
    pfam14914
    Location:586708
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
  2. NM_199340.5NP_955372.2  leucine-rich repeat-containing protein 37A3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_955372.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB011135, AC103810, AK294371, AK315945, BI560889
    Consensus CDS
    CCDS32708.1
    UniProtKB/Swiss-Prot
    O60309
    Related
    ENSP00000464535.1, ENST00000584306.6
    Conserved Domains (5) summary
    sd00031
    Location:891914
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:14681590
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561629
    LRRC37; Leucine-rich repeat-containing protein 37 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    64854130..64919478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1233078..1569269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    197796..287327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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