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KCNA10 potassium voltage-gated channel subfamily A member 10 [ Homo sapiens (human) ]

Gene ID: 3744, updated on 13-Mar-2020

Summary

Official Symbol
KCNA10provided by HGNC
Official Full Name
potassium voltage-gated channel subfamily A member 10provided by HGNC
Primary source
HGNC:HGNC:6219
See related
Ensembl:ENSG00000143105 MIM:602420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Kcn1; Kv1.8
Summary
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See KCNA10 in Genome Data Viewer
Location:
1p13.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (110517217..110519175, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (111059839..111061797, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378898 Neighboring gene CYMP antisense RNA 1 Neighboring gene chymosin, pseudogene Neighboring gene potassium voltage-gated channel subfamily A member 2 Neighboring gene uncharacterized LOC107985174 Neighboring gene potassium voltage-gated channel subfamily A member 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular cyclic nucleotide activated cation channel activity TAS
Traceable Author Statement
more info
PubMed 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IC
Inferred by Curator
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 10
Names
cyclic GMP gated potassium channel
potassium channel, voltage gated shaker related subfamily A, member 10
potassium voltage-gated channel, shaker-related subfamily, member 10
voltage-gated potassium channel subunit Kv1.8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005549.2NP_005540.1  potassium voltage-gated channel subfamily A member 10

    See identical proteins and their annotated locations for NP_005540.1

    Status: REVIEWED

    Source sequence(s)
    AL358215
    Consensus CDS
    CCDS826.1
    UniProtKB/Swiss-Prot
    Q16322
    Related
    ENSP00000358786.2, ENST00000369771.4
    Conserved Domains (2) summary
    pfam00520
    Location:255467
    Ion_trans; Ion transport protein
    pfam02214
    Location:88179
    BTB_2; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    110517217..110519175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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