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KCNA10 potassium voltage-gated channel subfamily A member 10 [ Homo sapiens (human) ]

Gene ID: 3744, updated on 11-Apr-2024


Official Symbol
KCNA10provided by HGNC
Official Full Name
potassium voltage-gated channel subfamily A member 10provided by HGNC
Primary source
See related
Ensembl:ENSG00000143105 MIM:602420; AllianceGenome:HGNC:6219
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Kcn1; Kv1.8
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]
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Genomic context

Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (110517217..110519175, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (110532257..110534215, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (111059839..111061797, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378898 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr1:111019910-111020410 and GRCh37_chr1:111020411-111020911 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:111025901-111026479 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:111036419-111037385 Neighboring gene CYMP antisense RNA 1 Neighboring gene chymosin, pseudogene Neighboring gene uncharacterized LOC124904292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1175 Neighboring gene potassium voltage-gated channel subfamily A member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1472

Genomic regions, transcripts, and products


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
acts_upstream_of_or_within potassium ion transport IDA
Inferred from Direct Assay
more info
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in plasma membrane IC
Inferred by Curator
more info
located_in plasma membrane TAS
Traceable Author Statement
more info
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 10
cyclic GMP gated potassium channel
potassium channel, voltage gated shaker related subfamily A, member 10
potassium voltage-gated channel, shaker-related subfamily, member 10
voltage-gated potassium channel subunit Kv1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005549.2NP_005540.1  potassium voltage-gated channel subfamily A member 10

    See identical proteins and their annotated locations for NP_005540.1

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    ENSP00000358786.2, ENST00000369771.4
    Conserved Domains (2) summary
    Ion_trans; Ion transport protein
    BTB_2; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    110517217..110519175 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060925.1 Alternate T2T-CHM13v2.0

    110532257..110534215 complement
    GenBank, FASTA, Sequence Viewer (Graphics)