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Kcna10 potassium voltage-gated channel, shaker-related subfamily, member 10 [ Mus musculus (house mouse) ]

Gene ID: 242151, updated on 18-Sep-2024

Summary

Official Symbol
Kcna10provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related subfamily, member 10provided by MGI
Primary source
MGI:MGI:3037820
See related
Ensembl:ENSMUSG00000042861 AllianceGenome:MGI:3037820
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kcna8; Kv1.8; Gm1962
Summary
Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Is expressed in several structures, including inner ear and skeletal muscle. Used to study vestibular disease. Orthologous to human KCNA10 (potassium voltage-gated channel subfamily A member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Kcna10 in Genome Data Viewer
Location:
3 F2.3; 3 46.64 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107090459..107103037)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107183143..107195721)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AI504432 Neighboring gene predicted gene, 38712 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E4573 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:106883731-106883985 Neighboring gene STARR-positive B cell enhancer ABC_E7937 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 2 Neighboring gene STARR-seq mESC enhancer starr_08660 Neighboring gene RIKEN cDNA A630076J17 gene Neighboring gene STARR-positive B cell enhancer ABC_E6103 Neighboring gene chymosin Neighboring gene prokineticin 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1)  1 citation

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 10
Names
cyclic GMP gated potassium channel
potassium voltage gated channel, shaker related subfamily, member 8
voltage-gated potassium channel subunit Kv1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081140.1NP_001074609.1  potassium voltage-gated channel subfamily A member 10

    See identical proteins and their annotated locations for NP_001074609.1

    Status: PROVISIONAL

    Source sequence(s)
    AC121825, AC132405
    Consensus CDS
    CCDS38587.1
    UniProtKB/Swiss-Prot
    B2RQA1, B2RXZ4
    Related
    ENSMUSP00000088118.6, ENSMUST00000055064.8
    Conserved Domains (4) summary
    smart00225
    Location:88171
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:267467
    Ion_trans; Ion transport protein
    pfam02214
    Location:88179
    BTB_2; BTB/POZ domain
    pfam07885
    Location:382458
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    107090459..107103037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)