Format

Send to:

Choose Destination

KCNA7 potassium voltage-gated channel subfamily A member 7 [ Homo sapiens (human) ]

Gene ID: 3743, updated on 13-Mar-2020

Summary

Official Symbol
KCNA7provided by HGNC
Official Full Name
potassium voltage-gated channel subfamily A member 7provided by HGNC
Primary source
HGNC:HGNC:6226
See related
Ensembl:ENSG00000104848 MIM:176268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HAK6; KV1.7
Summary
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See KCNA7 in Genome Data Viewer
Location:
19q13.33
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49067418..49072941, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49570675..49576198, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene chorionic gonadotropin subunit beta 7 Neighboring gene neurotrophin 4 Neighboring gene RNA, 7SL, cytoplasmic 708, pseudogene Neighboring gene small nuclear ribonucleoprotein U1 subunit 70

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 7
Names
potassium channel, voltage gated shaker related subfamily A, member 7
potassium voltage-gated channel, shaker-related subfamily, member 7
voltage-dependent potassium channel Kv1.7
voltage-gated potassium channel KCNA7
voltage-gated potassium channel subunit Kv1.7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031886.2NP_114092.2  potassium voltage-gated channel subfamily A member 7

    See identical proteins and their annotated locations for NP_114092.2

    Status: REVIEWED

    Source sequence(s)
    AJ310479
    Consensus CDS
    CCDS12755.1
    UniProtKB/Swiss-Prot
    Q96RP8
    Related
    ENSP00000221444.1, ENST00000221444.1
    Conserved Domains (4) summary
    smart00225
    Location:1598
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:200404
    Ion_trans; Ion transport protein
    pfam02214
    Location:15105
    BTB_2; BTB/POZ domain
    pfam07885
    Location:319398
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49067418..49072941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center