MSTN myostatin [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: MSTNprovided by CGNC
Official Full Name: myostatinprovided by CGNC
Primary source: CGNC:16892
See related: Ensembl:ENSGALG00010012852
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: GDF8; GDF-8
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	7	NC_052538.1 (305390..312076)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	7	NC_052579.1 (243681..250367)

Chromosome 7 - NC_052538.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Beneficial impact of dietary methyl methionine sulfonium chloride and/or L-carnitine supplementation on growth performance, feed efficiency, and serum biochemical parameters in broiler chicken: role of IGF-1 and MSTN genes.
Title: Beneficial impact of dietary methyl methionine sulfonium chloride and/or L-carnitine supplementation on growth performance, feed efficiency, and serum biochemical parameters in broiler chicken: role of IGF-1 and MSTN genes.
Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken.
Title: Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken.
MSTN regulates myogenesis by promoting EMT during somitogenesis.
Title: Myostatin promotes the epithelial-to-mesenchymal transition of the dermomyotome during somitogenesis.
Studied three chicken lines to identify the polymorphism in the coding region of the myostatin gene.
Title: Gene Expression and Polymorphism of Myostatin Gene and its Association with Growth Traits in Chicken.
The c.234G>A substitution in the myostatin (MSTN) gene negatively regulates the expression of MSTN in the Bian chicken and that it may be used in marker-assisted selection to accelerate the chicken breeding process.
Title: Functional identification of an exon 1 substitution in the myostatin gene and its expression in breast and leg muscle of the Bian chicken.
These data imply that alternative splicing isoforms of MSTN could negatively regulate pro-myostatin processing in muscle cells and prevent MSTN-mediated inhibition of myogenesis in chickens, turkeys, and quail.
Title: A novel mechanism of myostatin regulation by its alternative splicing variant during myogenesis in avian species.
The body weight gain and breast muscle yield of light chicks were improved by increasing dietary Methionine levels probably through alterations of MSTN transcription and phosphorylation of mTOR and FoxO4.
Title: MSTN, mTOR and FoxO4 are involved in the enhancement of breast muscle growth by methionine in broilers with lower hatching weight.
Low daily feed intake did not alter the trend in myostatin (MSTN) mRNA expression levels in either line, but significantly changed the peak values. Myogenin (MYOG) mRNA expression varied by line and over time, with a delay in the Lean line.
Title: Changes to daily feed intake during the laying period alters embryonic MSTN and MYOG gene expression in genetically fat and lean lines of chickens.
In conclusion, these studies suggested the decorin-mediated myostatin/Smad signaling pathway might be involved in the regulation of avian myoblast proliferation.
Title: Decorin-induced proliferation of avian myoblasts involves the myostatin/Smad signaling pathway.
results suggested that the E-boxes in the chicken MSTN promoter region are involved in the regulation of myostatin expression and the polymorphisms in E3 and E4 altered the expression of myostatin.
Title: Single nucleotide polymorphisms in the upstream regulatory region alter the expression of myostatin.

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General gene information

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Markers

GDF8 (e-PCR), detects polymorphism
- UniSTS:505475

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: growth/differentiation factor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.