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KCNA4 potassium voltage-gated channel subfamily A member 4 [ Homo sapiens (human) ]

Gene ID: 3739, updated on 7-Dec-2018

Summary

Official Symbol
KCNA4provided by HGNC
Official Full Name
potassium voltage-gated channel subfamily A member 4provided by HGNC
Primary source
HGNC:HGNC:6222
See related
Ensembl:ENSG00000182255 MIM:176266
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HK1; HBK4; PCN2; HPCN2; HUKII; KCNA8; KV1.4; KCNA4L
Summary
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]
Expression
Biased expression in adrenal (RPKM 3.8), brain (RPKM 1.8) and 4 other tissues See more
Orthologs

Genomic context

See KCNA4 in Genome Data Viewer
Location:
11p14.1
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (30009741..30017030, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (30031288..30038577, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 58 Neighboring gene long intergenic non-protein coding RNA 1616 Neighboring gene uncharacterized LOC107984321 Neighboring gene uncharacterized LOC105376607 Neighboring gene follicle stimulating hormone subunit beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Voltage gated Potassium channels, organism-specific biosystem (from REACTOME)
    Voltage gated Potassium channels, organism-specific biosystemVoltage-gated K+ channels (Kv) determine the excitability of heart, brain and skeletal muscle cells. Kv form octameric channel with alpha subunits that forms the pore of the channel and associated be...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
voltage-gated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 4
Names
cardiac potassium channel
fetal skeletal muscle potassium channel
potassium channel 2
potassium channel, voltage gated shaker related subfamily A, member 4
rapidly inactivating potassium channel
shaker-related potassium channel Kv1.4
type A potassium channel
voltage-gated K(+) channel HuKII
voltage-gated potassium channel HBK4
voltage-gated potassium channel HK1
voltage-gated potassium channel subunit Kv1.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042309.1 RefSeqGene

    Range
    5001..12290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002233.4NP_002224.1  potassium voltage-gated channel subfamily A member 4

    See identical proteins and their annotated locations for NP_002224.1

    Status: REVIEWED

    Source sequence(s)
    AC124657, AK311228, BE467209, DA328650, M60450
    Consensus CDS
    CCDS41629.1
    UniProtKB/Swiss-Prot
    P22459
    Related
    ENSP00000328511.6, ENST00000328224.6
    Conserved Domains (3) summary
    pfam00520
    Location:306570
    Ion_trans; Ion transport protein
    pfam02214
    Location:178266
    BTB_2; BTB/POZ domain
    pfam07941
    Location:137
    K_channel_TID; Potassium channel Kv1.4 tandem inactivation domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    30009741..30017030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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