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Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 [ Mus musculus (house mouse) ]

Gene ID: 16492, updated on 19-Sep-2024

Summary

Official Symbol
Kcna4provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related subfamily, member 4provided by MGI
Primary source
MGI:MGI:96661
See related
Ensembl:ENSMUSG00000042604 AllianceGenome:MGI:96661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kv1.4
Summary
Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within regulation of ion transmembrane transport. Located in axon initial segment and membrane. Is expressed in brain; heart; and hindlimb muscle. Orthologous to human KCNA4 (potassium voltage-gated channel subfamily A member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 2.0), cortex adult (RPKM 1.3) and 6 other tissues See more
Orthologs
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Genomic context

See Kcna4 in Genome Data Viewer
Location:
2 E3; 2 56.12 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (107120934..107157149)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (107290589..107326804)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05336 Neighboring gene follicle stimulating hormone beta Neighboring gene STARR-seq mESC enhancer starr_05337 Neighboring gene STARR-seq mESC enhancer starr_05338 Neighboring gene predicted gene, 39903 Neighboring gene predicted gene, 54140

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC124445

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of presynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in axon initial segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 4
Names
voltage-gated potassium channel subunit Kv1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021275.5NP_067250.2  potassium voltage-gated channel subfamily A member 4

    See identical proteins and their annotated locations for NP_067250.2

    Status: VALIDATED

    Source sequence(s)
    BX293548
    Consensus CDS
    CCDS16505.1
    UniProtKB/Swiss-Prot
    Q61423, Q8CBF8
    Related
    ENSMUSP00000037958.3, ENSMUST00000037012.3
    Conserved Domains (3) summary
    cl38908
    Location:177304
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:307571
    Ion_trans; Ion transport protein
    pfam07941
    Location:137
    K_channel_TID; Potassium channel Kv1.4 tandem inactivation domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    107120934..107157149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498812.3XP_006498875.1  potassium voltage-gated channel subfamily A member 4 isoform X1

    See identical proteins and their annotated locations for XP_006498875.1

    UniProtKB/Swiss-Prot
    Q61423, Q8CBF8
    Conserved Domains (3) summary
    cl38908
    Location:177304
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:307571
    Ion_trans; Ion transport protein
    pfam07941
    Location:137
    K_channel_TID; Potassium channel Kv1.4 tandem inactivation domain