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JUNB JunB proto-oncogene, AP-1 transcription factor subunit [ Homo sapiens (human) ]

Gene ID: 3726, updated on 3-Dec-2017
Official Symbol
JUNBprovided by HGNC
Official Full Name
JunB proto-oncogene, AP-1 transcription factor subunitprovided by HGNC
Primary source
HGNC:HGNC:6205
See related
Ensembl:ENSG00000171223 MIM:165161; Vega:OTTHUMG00000180373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP-1
Orthologs
Location:
19p13.13
Exon count:
1
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (12791496..12793311)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12902310..12904125)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene hook microtubule tethering protein 2 Neighboring gene microRNA 5684 Neighboring gene peroxiredoxin 2 Neighboring gene ribonuclease H2 subunit A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of jun B proto-oncogene (JUNB) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of JunB is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor PubMed
matrix gag HIV-1 matrix activates monocytes to produce MCP-1, which depends on the binding activity of AP-1 complexes (c-Fos/JunB) in the MCP-1 promoter PubMed

Go to the HIV-1, Human Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
decidualization IEA
Inferred from Electronic Annotation
more info
 
embryonic process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
osteoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
response to cAMP IBA
Inferred from Biological aspect of Ancestor
more info
 
response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
 
response to drug IBA
Inferred from Biological aspect of Ancestor
more info
 
response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
 
response to mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
response to radiation IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
trophectodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin TAS
Traceable Author Statement
more info
PubMed 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor AP-1 complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transcription factor jun-B
Names
activator protein 1
jun B proto-oncogene

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002229.2NP_002220.1  transcription factor jun-B

    See identical proteins and their annotated locations for NP_002220.1

    Status: VALIDATED

    Source sequence(s)
    BC009466
    Consensus CDS
    CCDS12280.1
    UniProtKB/Swiss-Prot
    P17275
    UniProtKB/TrEMBL
    Q5U079
    Related
    ENSP00000303315.4, OTTHUMP00000264124, ENST00000302754.5, OTTHUMT00000451015
    Conserved Domains (2) summary
    cd14696
    Location:270329
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
    pfam03957
    Location:5257
    Jun; Jun-like transcription factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

    Range
    12791496..12793311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    12902786..12904601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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