U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Topors Topoisomerase I-interacting protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37188, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Toporsprovided by FlyBase
Official Full Name
Topoisomerase I-interacting proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0267351
Locus tag
Dmel_CG15104
See related
AllianceGenome:FB:FBgn0267351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15104; Dmel\CG15104; dtopors; dTopors; nbl; TOPORS
Summary
Enables lamin binding activity and ubiquitin protein ligase activity. Involved in several processes, including cellular protein metabolic process; male meiosis chromosome segregation; and meiotic chromosome condensation. Located in nuclear lamina and polytene chromosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Topors in Genome Data Viewer
Location:
56A2-56A2; 2-87 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18972612..18977262)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14860117..14864767)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene proliferation disrupter Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene thin Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nuclear structure and chromosome segregation in Drosophila male meiosis depend on the ubiquitin ligase dTopors. Matsui M, et al. Genetics, 2011 Nov. PMID 21900273, Free PMC Article
  2. Roles of chromatin insulator proteins in higher-order chromatin organization and transcription regulation. Vogelmann J, et al. Nucleus, 2011 Sep-Oct. PMID 21983085, Free PMC Article
  3. SUMO conjugation attenuates the activity of the gypsy chromatin insulator. Capelson M, et al. EMBO J, 2006 May 3. PMID 16628226, Free PMC Article
  4. The ubiquitin ligase dTopors directs the nuclear organization of a chromatin insulator. Capelson M, et al. Mol Cell, 2005 Oct 7. PMID 16209949
  5. Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein. Secombe J, et al. J Biol Chem, 2004 Apr 23. PMID 14871887

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dtopors plays a structural role in spermatocyte lamina that is critical for multiple aspects of meiotic chromosome transmission
    Title: Nuclear structure and chromosome segregation in Drosophila male meiosis depend on the ubiquitin ligase dTopors.
  2. Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein
    Title: Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SUMO transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lamin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in centrosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear lamina IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
topoisomerase I-interacting protein
Names
CG15104-PA
CG15104-PB
Topors-PA
Topors-PB
nuclear blebber

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18972612..18977262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274154.1 → NP_001261083.1  topoisomerase I-interacting protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261083.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V8P9
    UniProtKB/TrEMBL
    A0A0B4KEZ9
    Conserved Domains (1) summary
    cd00162
    Location:102 → 144
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. NM_137544.3 → NP_611388.1  topoisomerase I-interacting protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611388.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V8P9
    UniProtKB/TrEMBL
    A0A0B4KEZ9
    Related
    FBpp0085754
    Conserved Domains (1) summary
    cd00162
    Location:102 → 144
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEZ9 A0A0B4KEZ9
Q9V8P9.1 Q9V8P9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools