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JAG2 jagged canonical Notch ligand 2 [ Homo sapiens (human) ]

Gene ID: 3714, updated on 13-Mar-2020

Summary

Official Symbol
JAG2provided by HGNC
Official Full Name
jagged canonical Notch ligand 2provided by HGNC
Primary source
HGNC:HGNC:6189
See related
Ensembl:ENSG00000184916 MIM:602570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HJ2; SER2
Summary
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in skin (RPKM 13.9), fat (RPKM 7.0) and 19 other tissues See more
Orthologs

Genomic context

See JAG2 in Genome Data Viewer
Location:
14q32.33
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (105140981..105168776, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105607318..105635161, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 132 Neighboring gene long intergenic non-protein coding RNA 2298 Neighboring gene microRNA 6765 Neighboring gene nudix hydrolase 14 Neighboring gene BRF1 RNA polymerase III transcription initiation factor subunit Neighboring gene BTB domain containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Notch signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Notch signaling pathway TAS
Traceable Author Statement
more info
 
T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
auditory receptor cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
epithelial cell apoptotic process involved in palatal shelf morphogenesis IEA
Inferred from Electronic Annotation
more info
 
gamma-delta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
morphogenesis of embryonic epithelium IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
respiratory system process IEA
Inferred from Electronic Annotation
more info
 
skeletal system development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
thymic T cell selection IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein jagged-2
Names
jagged 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002226.5NP_002217.3  protein jagged-2 isoform a precursor

    See identical proteins and their annotated locations for NP_002217.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA775404, AF003521, AF029778, AI276672, AJ712299, AL512356, BX105691, U69180
    Consensus CDS
    CCDS9998.1
    UniProtKB/Swiss-Prot
    Q9Y219
    Related
    ENSP00000328169.3, ENST00000331782.8
    Conserved Domains (5) summary
    smart00215
    Location:872943
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:307345
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:351381
    EGF; EGF-like domain
    pfam01414
    Location:178240
    DSL; Delta serrate ligand
    pfam07657
    Location:28102
    MNNL; N terminus of Notch ligand
  2. NM_145159.3NP_660142.1  protein jagged-2 isoform b precursor

    See identical proteins and their annotated locations for NP_660142.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform b) than isoform a encoded by variant 1. Isoform b is also known as hJAG2.del-E6.
    Source sequence(s)
    AA775404, AF003521, AF029779, AI276672, AJ712299, AL512356, BX105691, U69180
    Consensus CDS
    CCDS9999.1
    UniProtKB/Swiss-Prot
    Q9Y219
    Related
    ENSP00000328566.2, ENST00000347004.2
    Conserved Domains (5) summary
    smart00215
    Location:834905
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:307345
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:351381
    EGF; EGF-like domain
    pfam01414
    Location:178240
    DSL; Delta serrate ligand
    pfam07657
    Location:28102
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    105140981..105168776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001750303.2 RNA Sequence

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